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Articles Published Processes
12/2/2014 10:47:00 AM | Browse: 1239 | Download: 1582
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Received |
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2014-05-30 08:19 |
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Peer-Review Started |
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2014-05-30 19:37 |
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To Make the First Decision |
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2014-07-09 12:09 |
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Return for Revision |
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2014-07-17 15:24 |
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Revised |
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2014-07-24 23:56 |
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Second Decision |
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2014-09-05 16:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-09-05 17:16 |
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Articles in Press |
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2014-09-05 17:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-11-16 21:00 |
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Publish the Manuscript Online |
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2014-12-02 10:46 |
Category |
Oncology |
Manuscript Type |
Topic Highlights |
Article Title |
Causes and consequences of microsatellite instability in gastric carcinogenesis
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Manuscript Source |
Invited Manuscript |
All Author List |
Sérgia Velho, Maria Sofia Fernandes, Marina Leite, Ceu Figueiredo and Raquel Seruca |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
FEDER through Programa Operacional Factores de Competitividade - COMPETE |
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National Funds |
FCOMP-01-0124-FEDER-000022 |
Fundação para a Ciência e a Tecnologia (FCT) |
IF/00136/2013 (to Velho S) |
Fundação para a Ciência e a Tecnologia (FCT) |
SFRH/BPD/63716/2009 (to Fernandes MS) |
Fundação para a Ciência e a Tecnologia (FCT) |
SFRH/BPD/33420/2008 (to Leite M) |
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Corresponding Author |
Raquel Seruca, MD, PhD, IPATIMUP- Institute of Molecular Pathology and Immunology of the University of Porto, Rua D. Manuel II s/n, 4200-465 Porto, Portugal. rseruca@ipatimup.pt |
Key Words |
Gastric cancer; Microsatellite instability; Mismatch repair genes; Oncogenes; Helicobacter pylori |
Core Tip |
This review summarizes the current knowledge on the molecular mechanisms underlying the acquisition of microsatellite instability (MSI) in gastric cancer (gc) as well as on the clinic, pathologic and molecular consequences of the MSI phenotype. Additionally, current therapeutic strategies for gc and their applicability in the MSI subset are also discussed. |
Publish Date |
2014-12-02 10:46 |
Citation |
Velho S, Fernandes MS, Leite M, Figueiredo C, Seruca R. Causes and consequences of microsatellite instability in gastric carcinogenesis. World J Gastroenterol 2014; 20(44): 16433-16442 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i44/16433.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i44.16433 |
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