BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/9/2026 9:45:02 AM | Browse: 3 | Download: 44
 |
Received |
|
2025-11-24 06:14 |
|
Peer-Review Started |
|
2025-11-24 07:28 |
|
First Decision by Editorial Office Director |
|
2025-12-23 10:02 |
|
Return for Revision |
|
2025-12-23 10:02 |
|
Revised |
|
2026-01-06 05:56 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-01-19 02:44 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-01-19 04:51 |
|
Articles in Press |
|
2026-01-19 04:51 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-08-19 06:43 |
|
Publish the Manuscript Online |
|
2026-09-09 09:45 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Correspondence |
| Article Title |
GEN1 as a potential therapeutic target in gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yusuf Tutar |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Yusuf Tutar, Chairman, Dean, Tenured Professor, Department of Basic Medical Sciences, Division of Medicinal Biochemistry, Recep Tayyip Erdogan University, Islampaşa, Rize 53020, None Selected, Türkiye. yusuf.tutar@erdogan.edu.tr |
| Key Words |
GEN1; Gastric cancer; Ferroptosis; Mitochondrial dysfunction; Cell cycle; Chemotherapy sensitivity |
| Core Tip |
Gastric cancer (GC) growth is driven by complex molecular pathways including genomic instability, cell cycle dysregulation, mitochondrial dysfunction, and ferroptosis. Novel data suggest that GEN1, a Holliday junction resolvase involved in DNA repair, is a key oncogenic regulator in GC that promotes tumor cell proliferation, migration, survival, and chemoresistance, and modulates ferroptosis-related pathways, suggesting that GEN1 may be a therapeutic target and that adding molecular markers related to DNA damage responses may enhance diagnostic accuracy and therapy stratification in GC. |
| Publish Date |
2026-09-09 09:45 |
| Citation |
Tutar Y. GEN1 as a potential therapeutic target in gastric cancer. World J Gastrointest Oncol 2026; 18(9): 116896
|
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i9/116896.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i9.116896 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
