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Articles Published Processes
6/30/2026 1:40:20 PM | Browse: 0 | Download: 0
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Received |
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2025-11-27 00:57 |
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Peer-Review Started |
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2025-11-27 07:28 |
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First Decision by Editorial Office Director |
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2026-01-15 07:17 |
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Return for Revision |
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2026-01-15 07:17 |
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Revised |
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2026-01-23 05:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-25 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-25 09:42 |
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Articles in Press |
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2026-02-25 09:42 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-26 03:28 |
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Publish the Manuscript Online |
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2026-06-30 13:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Echoes of ancient wisdom and synergistic strategies invigorate the fight against liver fibrosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Bing Wang, Yuan Li, Ying-Yu Wang, Wei-Qi Liu, Xiang Xu and Ming-Ming Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Municipal Natural Science Foundation of China |
7252093 |
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| Corresponding Author |
Ming-Ming Liu, Associate Professor, PhD, Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 5 Dongdan Third Alley, Dongcheng District, Beijing 100005, China. mingmingliu@imc.pumc.edu.cn |
| Key Words |
Liver fibrosis; Systems pharmacology; Network medicine; Bioactivity-based quality control; Drug synergism |
| Core Tip |
The failure of reductionist magic bullet therapies in liver fibrosis necessitates a shift toward systems pharmacology and network regulation. The Crocus sativus-Calculus Bovis pair validates this approach by simultaneously modulating the p38 MAPK and TGF-β/Smad axes to collapse the fibrogenic network. Clinical success depends on evolving from chemical standardization to bioactivity-linked quality control and adopting precision medicine to stratify patient endotypes. |
| Publish Date |
2026-06-30 13:40 |
| Citation |
Wang B, Li Y, Wang YY, Liu WQ, Xu X, Liu MM. Echoes of ancient wisdom and synergistic strategies invigorate the fight against liver fibrosis. World J Gastroenterol 2026; 32(26): 116924
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i26/116924.htm |
| DOI |
https://doi.org/10.3748/wjg.116924 |
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