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Articles Published Processes
8/7/2026 9:40:26 AM | Browse: 2 | Download: 0
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Received |
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2025-11-26 03:36 |
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Peer-Review Started |
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2025-11-26 03:43 |
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First Decision by Editorial Office Director |
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2025-12-12 08:00 |
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Return for Revision |
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2025-12-12 08:00 |
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Revised |
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2026-01-11 10:31 |
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Publication Fee Transferred |
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2026-01-16 03:58 |
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Second Decision by Editor |
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2026-03-03 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-03 09:14 |
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Articles in Press |
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2026-03-03 09:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-24 00:35 |
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Publish the Manuscript Online |
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2026-08-07 09:40 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
TCHP regulates the proliferation and apoptosis of gastric cancer cells via AKT/BCL2 signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue Wang, Ting-Yu Zhang, Yan-Feng Shen, Na Shen and Zhi-Wei Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Cooperative Project of the Affiliated Hospital of Hebei University of Engineering |
KFKT2024-05 |
| Precision Medicine Joint Cultivation Fund Project of Hebei Natural Science Foundation |
H2021402007 |
| Science Research Project of Hebei Education Department |
QN2020234 |
| Handan Key Laboratory Project of Precision Diagnosis and Treatment of Digestive Tract Cancer |
23313014021 |
| Scientific Research Project of the Administration of Traditional Chinese Medicine of Hebei Province |
2022149 |
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| Corresponding Author |
Zhi-Wei Zhang, PhD, Vice Director, Department of Oncology, Affiliated Hospital of Hebei University of Engineering, No. 81 Congtai Road, Congtai District, Handan 056002, Hebei Province, China. zhangzw128@126.com |
| Key Words |
Gastric cancer; TCHP; Proliferation; Apoptosis; AKT; BCL2 |
| Core Tip |
The function and molecular mechanism of TCHP is poorly understood in gastric cancer (GC). This study investigated the role of the centrosomal protein TCHP in GC progression. TCHP was highly expressed in GC cells, and it significantly inhibited cell proliferation, arrested the cell cycle at G1 phase, and promoted apoptosis. Proteomic analysis revealed that TCHP influenced apoptosis via AKT/BCL2 pathway. In vivo experiments further confirmed that TCHP knockdown suppressed tumor growth. These results demonstrate that TCHP promotes GC proliferation and inhibits apoptosis by activating the AKT/BCL2 pathway, suggesting its potential as a therapeutic target in GC. |
| Publish Date |
2026-08-07 09:40 |
| Citation |
Wang Y, Zhang TY, Shen YF, Shen N, Zhang ZW. TCHP regulates the proliferation and apoptosis of gastric cancer cells via AKT/BCL2 signaling pathway. World J Gastrointest Oncol 2026; 18(8): 116937
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i8/116937.htm |
| DOI |
https://doi.org/10.4251/wjgo.116937 |
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