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Articles Published Processes
4/8/2026 7:28:55 AM | Browse: 0 | Download: 0
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Received |
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2025-12-02 02:04 |
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Peer-Review Started |
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2025-12-02 02:04 |
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First Decision by Editorial Office Director |
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2025-12-09 10:07 |
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Return for Revision |
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2025-12-10 13:51 |
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Revised |
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2025-12-16 10:39 |
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Publication Fee Transferred |
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2026-01-08 08:45 |
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Second Decision by Editor |
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2026-02-28 02:30 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-28 08:12 |
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Articles in Press |
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2026-02-28 08:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-27 03:50 |
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Publish the Manuscript Online |
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2026-04-08 07:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Uncommon hepatocellular carcinoma in a non-cirrhotic woman with chronic hepatitis B virus infection after medical assisted reproduction: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Clelia Asero, Giuliana Ciappina, Maria Stella Franzè, Teresa Maltese, Salvatore Gruttadauria, Duilio Pagano, Daniele Lombardo, Alessia Pitrone, Cristina Musolino, Massimiliano Berretta and Irene Cacciola |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministero dell’Università e della Ricerca |
PRIN_2022PNRR_P2022KCHLN_002 - CUP J53D23018010001 |
| Ministero dell’Università e della Ricerca |
CUP J43C22000310006 ID ECS00000022 |
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| Corresponding Author |
Irene Cacciola, MD, Professor, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria 1, Messina 98124, Sicilia, Italy. icacciola@unime.it |
| Key Words |
Hepatocellular carcinoma; Chronic hepatitis B; Pregnancy; Reproductive techniques; Oestrogens; Case report |
| Core Tip |
Hepatocellular carcinoma is rare during pregnancy and is associated with adverse outcomes for both the mother and the foetus. We report the case of a 46-year-old woman with HBeAg-negative chronic hepatitis B infection (HBV) who developed recurrent hepatocellular carcinoma after a pregnancy achieved through medically assisted reproduction. After surgical resection, immunofluorescence analysis of tumour samples showed no expression of oestrogen receptors, while molecular analyses performed on tumour and non-tumour tissues revealed high levels of total HBV DNA, HBV covalently closed circular DNA and HBV RNA, suggesting a virus-host interaction that may account for the aggressive behaviour of the neoplasm. |
| Publish Date |
2026-04-08 07:28 |
| Citation |
Asero C, Ciappina G, Franzè MS, Maltese T, Gruttadauria S, Pagano D, Lombardo D, Pitrone A, Musolino C, Berretta M, Cacciola I. Uncommon hepatocellular carcinoma in a non-cirrhotic woman with chronic hepatitis B virus infection after medical assisted reproduction: A case report. World J Gastrointest Oncol 2026; 18(4): 116955 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i4/116955.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i4.116955 |
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