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Articles Published Processes
5/26/2026 3:52:10 AM | Browse: 1 | Download: 0
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Received |
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2025-11-26 02:45 |
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Peer-Review Started |
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2025-11-26 03:30 |
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First Decision by Editorial Office Director |
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2026-01-09 08:57 |
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Return for Revision |
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2026-01-09 08:57 |
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Revised |
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2026-01-23 12:15 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-04 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-04 07:36 |
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Articles in Press |
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2026-03-04 07:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-14 08:19 |
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Publish the Manuscript Online |
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2026-05-26 03:52 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Iqra Arshad, Mashaim Majid, Bisma Rauff, Ali Amar and Mahmood S Choudhery |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mahmood S Choudhery, Department of Human Genetics and Molecular Biology, University of Health Sciences Lahore, Lahore, Lahore 54000, Lahore, Pakistan. ms20031@yahoo.com |
| Key Words |
Chronic hepatitis C; IFI16; AIM2; Rs2814770; Rs1057028; Genetic polymorphism; Prognostic biomarker; Liver fibrosis; Cirrhosis; Hepatitis C virus |
| Core Tip |
Hepatic fibrosis progression in chronic hepatitis C (CHC) is influenced by complex immunogenetic factors. This study demonstrates that the AIM2 (rs2814770) TT genotype and combined carriage of variants rs1057028 (A allele) of IFI16 and rs2814770 (T allele) of AIM2 significantly increases the risk of advanced liver fibrosis in Pakistani CHC patients. A dose-dependent rise in fibrosis severity with increasing risk alleles further supports their pathogenic relevance. These findings suggest a potential role of IFI16 and AIM2 genetic variants as predictive biomarkers for fibrosis progression, underscoring the need for expanded studies to validate their clinical utility. |
| Publish Date |
2026-05-26 03:52 |
| Citation |
Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i5/116995.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i5.116995 |
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