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Articles Published Processes
8/18/2026 3:51:54 AM | Browse: 0 | Download: 0
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Received |
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2025-11-26 02:33 |
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Peer-Review Started |
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2025-11-26 02:33 |
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First Decision by Editorial Office Director |
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2025-12-24 10:14 |
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Return for Revision |
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2025-12-24 10:14 |
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Revised |
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2026-01-02 18:28 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-01 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-01 12:18 |
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Articles in Press |
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2026-04-01 12:18 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-08 06:06 |
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Publish the Manuscript Online |
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2026-08-18 03:51 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Editorial |
| Article Title |
Hepatic ischemia reperfusion injury: Understanding the little components of the larger picture
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Eyad Abdulrazzak and Eric R Kallwitz |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Eric R Kallwitz, Associate Professor, Division of Hepatology, Department of Medicine, Loyola University Medical Center, 2160 S First Ave, Maywood, IL 60153, United States. ekallwitz@lumc.edu |
| Key Words |
Surgical complications; Liver allograft; Hepatocellular injury; Ischemia prevention; Organ preservation |
| Core Tip |
Despite advancements in surgical techniques and preservation, hepatic ischemia-reperfusion injury (H-IRI) remains a critical hurdle in liver transplantation, contributing to early allograft dysfunction. While machine perfusion represents a major macro-level advancement, pharmacological strategies targeting specific molecular pathways remain an important avenue for mitigating H-IRI. This editorial briefly outlines the complexity of H-IRI mechanisms, discusses emerging pharmacological and mechanical interventions, and highlights recent findings on the neurokinin-1 receptor antagonist aprepitant as a potential therapeutic agent. |
| Publish Date |
2026-08-18 03:51 |
| Citation |
Abdulrazzak E, Kallwitz ER. Hepatic ischemia reperfusion injury: Understanding the little components of the larger picture. World J Hepatol 2026; 18(8): 117012
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i8/117012.htm |
| DOI |
https://doi.org/10.4254/wjh.117012 |
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