| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Hypoxia-preconditioned adipose-derived stem cell exosomes promote osteogenic differentiation and bone formation in bone marrow mesenchymal stem cells through the Piezo1/Ca2+ signaling axis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wumiti Taxi, Jie Sun, Yi-Hua Zhu, Tian-Chi Zhang, Yang Guo, Ya-Lan Pan, Meng-Min Liu, Xi Chen, Chun-Lei Zhang, Kai Tong, Li-Ning Wang, Tao Jiang and Yong Ma |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82074458, 82174411, 82474549, 82505718 |
| Natural Science Foundation of Jiangsu Province |
BK20221351, BK20220470, BK20240745 |
| Jiangsu CM Clinical Innovation Center of Degenerative Bone and Joint Disease (Jiangsu Science and Education of Traditional Chinese Medicine) [2021] |
No. 4 |
| Natural Science Foundation of Jiangsu Higher Education Institutions |
22KJB360012 |
| Yancheng Basic Research Program General Project |
YCBK2024087 |
|
| Corresponding Author |
Yong Ma, Laboratory of New Techniques of Restoration & Reconstruction of Orthopedics and Traumatology, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210046, Jiangsu Province, China. mayong@njucm.edu.cn |
| Key Words |
Osteoporosis; Exosomes; Bone marrow mesenchymal stem cells; Hypoxia; Piezo1/Ca2+ axis |
| Core Tip |
This study reveals that exosomes derived from hypoxia-preconditioned adipose-derived stem cells significantly enhance osteogenic differentiation and bone formation through the Piezo1/calcium signaling axis. Hypoxia-preconditioned adipose-derived stem cells promote bone marrow mesenchymal stem cell mineralization and improve bone microarchitecture in an ovariectomized rat model. These effects are abolished by the Piezo1 inhibitor GsMTx4, identifying Piezo1 as a novel mechanistic target. Our findings propose a promising exosome-based strategy for the treatment of osteoporosis. |
| Publish Date |
2026-05-25 07:47 |
| Citation |
Taxi W, Sun J, Zhu YH, Zhang TC, Guo Y, Pan YL, Liu MM, Chen X, Zhang CL, Tong K, Wang LN, Jiang T, Ma Y. Hypoxia-preconditioned adipose-derived stem cell exosomes promote osteogenic differentiation and bone formation in bone marrow mesenchymal stem cells through the Piezo1/Ca2+ signaling axis. World J Stem Cells 2026; 18(5): 117045 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i5/117045.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i5.117045 |
