| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
PIGU overexpression and regulation of cellular biological functions in bladder cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sheng-Hua Li, Zhi-Su Liu, Yu-Jia Chen, Jian-Di Li, Long Wei, Yi-Yang Chen, Wei Zhang, Zhi-Guang Huang, Zhen-Dong Chen, Gang Chen, Dan-Ming Wei, Zeng-Nan Mo and Li-Li Deng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. NSFC82260785 |
| Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project |
No. Z20201168 |
| Guangxi Medical University Digital Textbook Construction Project |
No. Gxmuszjc2515 |
| Guangxi Medical University Special Project on Educational and Teaching Reform for Clinical Disciplines |
No. 2025LCJG02 |
| Guangxi Medical University “Four New” Project |
No. SX202403 |
| China Undergraduate Innovation and Entrepreneurship Training Program |
No. S202310598074 |
|
| Corresponding Author |
Li-Li Deng, PhD, Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. denglily2003@126.com |
| Key Words |
PIGU; Bladder cancer; Immunohistochemistry; Cell cycle; Apoptosis; Prognosis; Immune infiltration |
| Core Tip |
This study indicated that PIGU expression is markedly increased in bladder cancer at both the mRNA and protein levels and that this elevation serves as an independent predictor of unfavorable clinical outcomes. In vitro experiments further revealed that PIGU knockdown suppresses cell proliferation and induces apoptosis accompanied by G1-phase arrest, while mechanistic analyses indicated that PIGU facilitates tumor progression by regulating key cell cycle-related genes and modulating the immune microenvironment. These results indicate that PIGU could function not only as an independent prognostic indicator but also as a promising candidate for therapeutic targets. |
| Publish Date |
2026-03-23 08:21 |
| Citation |
Li SH, Liu ZS, Chen YJ, Li JD, Wei L, Chen YY, Zhang W, Huang ZG, Chen ZD, Chen G, Wei DM, Mo ZN, Deng LL. PIGU overexpression and regulation of cellular biological functions in bladder cancer. World J Clin Oncol 2026; 17(3): 117055 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i3/117055.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i3.117055 |
