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Articles Published Processes
6/30/2026 11:45:06 AM | Browse: 9 | Download: 43
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Received |
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2026-01-09 10:03 |
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Peer-Review Started |
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2026-01-09 10:03 |
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First Decision by Editorial Office Director |
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2026-01-20 05:48 |
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Return for Revision |
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2026-01-20 05:48 |
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Revised |
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2026-02-09 09:34 |
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Publication Fee Transferred |
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2026-02-13 12:21 |
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Second Decision by Editor |
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2026-04-10 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-10 04:51 |
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Articles in Press |
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2026-04-10 04:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-15 02:21 |
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Publish the Manuscript Online |
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2026-06-30 11:45 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of apple phenols on anxiety/depression in a rat model of acute exacerbation of chronic obstructive pulmonary disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ping Feng, Ze-Xuan Ji, Hong-Yan Zhang, Kai-Yan Song, Li-Ping Chen, Hai-Hong Qian and Bu Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhangjiakou Science and Technology Bureau |
No. 2322090D |
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| Corresponding Author |
Bu Wang, Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. fp202508@163.com |
| Key Words |
Apple polyphenols; Acute exacerbation chronic obstructive pulmonary disease; Inflammatory; Anxiety-depression; NOD-like receptor protein 3 |
| Core Tip |
This study investigated the effects of apple polyphenols (AP) in a rat model of acute exacerbation of chronic obstructive pulmonary disease. Results demonstrated that AP treatment, particularly at high doses, effectively improved lung function and body weight and reduced pathological damage. It significantly downregulated the expression of NOD-like receptor protein 3 in lung tissue, leading to decreased levels of pro-inflammatory cytokines and oxidative stress markers in the serum, lung tissue, and prefrontal lobe tissue. Concurrently, AP alleviated anxiety and depression-like behaviors in acute exacerbation of chronic obstructive pulmonary disease model animals. This mechanism is associated with NOD-like receptor protein 3 pathway suppression. |
| Publish Date |
2026-06-30 11:45 |
| Citation |
Feng P, Ji ZX, Zhang HY, Song KY, Chen LP, Qian HH, Wang B. Effect of apple phenols on anxiety/depression in a rat model of acute exacerbation of chronic obstructive pulmonary disease. World J Psychiatry 2026; 16(7): 117078
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| URL |
https://www.wjgnet.com/2220-3206/full/v16/i7/117078.htm |
| DOI |
https://doi.org/10.5498/wjp.117078 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
