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Articles Published Processes
7/9/2026 6:58:25 AM | Browse: 0 | Download: 0
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Received |
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2025-12-05 01:46 |
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Peer-Review Started |
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2025-12-05 08:36 |
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First Decision by Editorial Office Director |
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2025-12-30 05:58 |
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Return for Revision |
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2025-12-30 05:58 |
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Revised |
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2026-01-06 14:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-05 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-05 07:38 |
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Articles in Press |
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2026-02-05 07:38 |
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Edit the Manuscript by Language Editor |
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2026-02-07 20:01 |
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Typeset the Manuscript |
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2026-06-26 12:48 |
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Publish the Manuscript Online |
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2026-07-09 06:58 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Leptin hypomethylation: An early epigenetic marker of lean-type diabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhong-Yi Zhao, Pan-Feng Wu and Nian-Zhe Sun |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nian-Zhe Sun, MD, PhD, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com |
| Key Words |
Epigenetic gene regulation; Lean type 2 diabetes; Leptin; DNA methylation; Disease progression prediction |
| Core Tip |
Epigenetic dysregulation of leptin (LEP) gene in lean Chinese patients with diabetes has been understudied. Sun et al performed a cross-sectional study to investigate the associations of LEP promoter methylation levels and serum leptin concentrations with diabetes progression in non-obese individuals (body mass index < 24 kg/m²). Findings indicated that in lean adult Chinese patients (body mass index < 24 kg/m²), the methylation of the LEP promoter gradually decreased during the progression of diabetes, demonstrating a significant inverse correlation with serum leptin levels. These findings imply that LEP promoter methylation may act as a potential biomarker for early risk stratification of diabetes and prediction of its severity in non-obese patients with diabetes. |
| Publish Date |
2026-07-09 06:58 |
| Citation |
Zhao ZY, Wu PF, Sun NZ. Letter to the Editor: Leptin hypomethylation: An early epigenetic marker of lean-type diabetes. World J Diabetes 2026; 17(7): 117113
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i7/117113.htm |
| DOI |
https://doi.org/10.4239/wjd.117113 |
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