| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Clinical Trial |
| Article Title |
Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Yuan Wang, Ke-Han Yin, Li Cheng, Xiao-Yu Wang, Ying Qiao, Xing-Ru Tang, Bo Wang, Xiu-Juan Yan and Sheng-Liang Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82570628 |
| National Natural Science Foundation of China |
82170554 |
| National Natural Science Foundation of China |
82300643 |
|
| Corresponding Author |
Sheng-Liang Chen, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai 200001, China. chenslmd@shsmu.edu.cn |
| Key Words |
Flupentixol-melitracen; Functional dyspepsia; Lansoprazole; Anxiety; Deanxit |
| Core Tip |
This randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of flupentixol-melitracen combined with lansoprazole for functional dyspepsia (FD). our study demonstrated that this low-dose short-term regimen not only improved FD symptoms and quality of life within two weeks but also sustained efficacy for four weeks post-treatment. Future long-term follow-up and multicenter studies are warranted to verify its lasting benefits and health economic value, potentially advancing FD management from a “stepwise sequential” approach to a “brain-gut co-management” therapy. |
| Publish Date |
2026-03-27 06:07 |
| Citation |
Wang XY, Yin KH, Cheng L, Wang XY, Qiao Y, Tang XR, Wang B, Yan XJ, Chen SL. Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial. World J Gastroenterol 2026; 32(13): 117115 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i13/117115.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i13.117115 |
