| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Gastric electrical stimulation ameliorates antral myenteric neurons in streptozotocin-induced diabetic beagle canines
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Pan Tang, Xin Wu, Ji-Ri Xi, Ming-Yu Fu, Xiao-Wei Xue, Ying Jiang, Yang Zhao, He-Er Yang, Gui-Jun Fei, Xiao-Qing Li, Chun-Hua Hu and Xiu-Cai Fang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Technologies Research and Development Program of China |
No. 2019YFC0118505 |
|
| Corresponding Author |
Xiu-Cai Fang, Professor, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China. fangxiucai2@aliyun.com |
| Key Words |
Diabetes gastroparesis; Gastric electrical stimulation; Choline acetyltransferase; Vasoactive intestinal peptide; Neuronal nitric oxide synthase; Enteric nervous system |
| Core Tip |
Experiments in small animal models have confirmed that damage to the enteric nervous system severely impairs physiological movement in the gastrointestinal system in diabetic gastroparesis. We found that the morphologic changes in gastric excitatory and inhibitory neurons are also present in streptozotocin-induced diabetic beagle canines, despite the absence of obvious manifestations of gastroparesis. High-frequency gastric electrical stimulation ameliorates the enteric nervous system in diabetic canines by upregulating choline acetyltransferase and neuronal nitric oxide synthase-immunoreactive positive neurons, these neuromodulatory effects on enteric neuronal plasticity could restore slow wave rhythms, enhance gastric emptying, and improve gastric accommodation. |
| Publish Date |
2026-05-11 09:00 |
| Citation |
Tang P, Wu X, Xi JR, Fu MY, Xue XW, Jiang Y, Zhao Y, Yang HE, Fei GJ, Li XQ, Hu CH, Fang XC. Gastric electrical stimulation ameliorates antral myenteric neurons in streptozotocin-induced diabetic beagle canines. World J Diabetes 2026; 17(5): 117132 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i5/117132.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i5.117132 |
