| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Overexpression and clinicopathological significance of cullin-2 in hepatocellular carcinoma progression
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Pan Tang, Qiu-Hong Nong, Kun-Hua Xiong, Huan-Huan Tang, Bei-Bei Huang, Guang-Lei Huang, Qi Li, Shi-Pei He, Gang Chen, Zhen-Bo Feng and Jian-Di Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fund of National Natural Science Foundation of China |
NSFC82260581 |
| the Innovation Project of Guangxi Graduate Education |
JGY2023068 |
| Guangxi Medical University “Four New” Project |
SX202403 |
| Guangxi Medical University Special Project on Educational and Teaching Reform for Clinical Disciplines |
2025LCJG02 |
| Guangxi Medical University Digital Textbook Construction Project |
Gxmuszjc2515 |
| the China Undergraduate Innovation and Entrepreneurship Training Program |
202510598040 |
| the Future Academic Star of Guangxi Medical University |
WLXSZX25B079 |
|
| Corresponding Author |
Jian-Di Li, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. jiandi_li_gxmu@163.com |
| Key Words |
Hepatocellular carcinoma; Cullin 2; Molecular biomarker; Molecular mechanisms; Prognosis; Targeted therapy |
| Core Tip |
Cullin-2 (CUL2) is highly expressed in mRNA and protein levels in hepatocellular carcinoma (HCC). Multicenter analysis (n = 5204) confirmed its high expression (standardized mean difference = 0.70) and diagnostic value (area under the curve = 0.78). The overall survival of patients with high expression was shortened by about 4.1 years. Functional enrichment showed that it was associated with E2F, G2/M and MYC pathways and promoted cell cycle progression. Knockout of CUL2 significantly inhibited the growth of HCC cells, indicating that CUL2 drives HCC progression through proliferation and migration. |
| Publish Date |
2026-03-26 09:22 |
| Citation |
Tang P, Nong QH, Xiong KH, Tang HH, Huang BB, Huang GL, Li Q, He SP, Chen G, Feng ZB, Li JD. Overexpression and clinicopathological significance of cullin-2 in hepatocellular carcinoma progression. World J Hepatol 2026; 18(3): 117134 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i3/117134.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i3.117134 |
