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Articles Published Processes
1/16/2026 3:25:53 AM | Browse: 2 | Download: 13
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Received |
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2025-12-01 00:44 |
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Peer-Review Started |
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2025-12-01 00:44 |
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First Decision by Editorial Office Director |
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2025-12-04 08:57 |
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Return for Revision |
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2025-12-04 08:57 |
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Revised |
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2025-12-15 19:02 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-25 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-25 08:56 |
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Articles in Press |
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2025-12-25 08:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-09 00:30 |
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Publish the Manuscript Online |
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2026-01-16 03:25 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Endocrine consequences of antifungal therapy: A missed entity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Simran Thakkar, Viny Kantroo, Lakshmi Nagendra, Deep Dutta, Abul Bashar Mohammad Kamrul-Hasan, Sanjay Kalra and Saptarshi Bhattacharya |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Saptarshi Bhattacharya, DM, MD, Department of Endocrinology, Indraprastha Apollo Hospitals, Delhi Mathura Road, New Delhi 110076, Delhi, India. saptarshi515@gmail.com |
| Key Words |
Voriconazole; Posaconazole; Adrenal insufficiency; Apparent mineralocorticoid excess; Ketoconazole; Amphotericin B; Antifungal therapy |
| Core Tip |
Antifungal drugs can interfere with key endocrine pathways by inhibiting steroidogenic enzymes or through drug–drug interactions that alter glucocorticoid and mineralocorticoid metabolism. Ketoconazole, fluconazole, itraconazole, posaconazole, and voriconazole demonstrate distinct endocrine adverse effects, ranging from adrenal insufficiency and apparent mineralocorticoid excess to reproductive dysfunction, hyponatremia, and fluoride-related periostitis. Amphotericin B primarily acts through renal tubular injury and associated electrolyte disturbances, whereas echinocandins rarely affect endocrine function. Recognizing these effects, especially in patients receiving multiple interacting medications, is essential for timely diagnosis and safe therapeutic decision-making. |
| Publish Date |
2026-01-16 03:25 |
| Citation |
Thakkar S, Kantroo V, Nagendra L, Dutta D, Kamrul-Hasan ABM, Kalra S, Bhattacharya S. Endocrine consequences of antifungal therapy: A missed entity. World J Clin Cases 2026; 14(2): 117140 |
| URL |
https://www.wjgnet.com/2307-8960/full/v14/i2/117140.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v14.i2.117140 |
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