| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Modified Hu-Lian-Bi-Guan decoction for wound healing in complex anal fistula: A randomized controlled trial
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Han-Wen Yang, Ting-Ting Li, Xin-Bo Song, Li-Xia Lai, Qiang Yu, Huang-Fu Ma, Yue Wang, Xue-Cheng Zhang, Xiao-Yu Chen, Shu-Xin Zhang and Jia-Nan Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National High Level Hospital Clinical Research Funding |
2023-NHLHCRF-YYPPLC-ZR-03 |
| National High Level Hospital Clinical Research Funding, Elite Medical Professionals Initiative of the China-Japan Friendship Hospital |
ZRJY2025-QM11 |
|
| Corresponding Author |
Jia-Nan Li, Department of Proctology, China-Japan Friendship Hospital, No. 2, Yingyuan Garden East Street, Chaoyang District, Beijing, Beijing 100029, China. wuqu3@163.com |
| Key Words |
Modified Hu-Lian-Bi-Guan decoction; Complex anal fistula; TGF-β/Smad signaling pathway; Epithelial-mesenchymal transition; Inflammatory factors |
| Core Tip |
This randomized controlled trial evaluates the efficacy of modified Hu-Lian-Bi-Guan decoction (mHLBGD) in enhancing postoperative wound healing for complex anal fistula (AF). The study demonstrates that mHLBGD significantly accelerates healing time and reduces postoperative pain compared to standard care. Mechanistically, the research highlights that mHLBGD promotes tissue repair by modulating inflammatory cytokines, regulating the TGF-β/Smad signaling pathway, and influencing epithelial-mesenchymal transition. These findings provide compelling clinical and molecular evidence supporting mHLBGD as an effective adjunctive therapy for complex AF recovery. |
| Publish Date |
2026-03-16 08:22 |
| Citation |
Yang HW, Li TT, Song XB, Lai LX, Yu Q, Ma HF, Wang Y, Zhang XC, Chen XY, Zhang SX, Li JN. Modified Hu-Lian-Bi-Guan decoction for wound healing in complex anal fistula: A randomized controlled trial. World J Gastroenterol 2026; 32(11): 117149 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i11/117149.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i11.117149 |
