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Articles Published Processes
3/15/2026 6:19:14 AM | Browse: 3 | Download: 1
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Received |
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2025-12-01 03:20 |
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Peer-Review Started |
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2025-12-01 03:21 |
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First Decision by Editorial Office Director |
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2026-01-12 09:13 |
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Return for Revision |
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2026-01-12 09:13 |
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Revised |
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2026-01-13 17:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-27 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-27 08:17 |
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Articles in Press |
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2026-02-27 08:17 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-04 02:03 |
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Publish the Manuscript Online |
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2026-03-15 06:19 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Myocardiocyte senescence in ischemic heart disease and breathome changes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Basheer Abdullah Marzoog and Philipp Kopylov |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Government Assignment «Application of Mass Spectrometry and Exhaled Air Emission Spectrometry for Cardiovascular Risk Stratification» |
No. 1023022600020-6 |
| the Priority 2030 Program of the Ministry of Science and Higher Education of Russia, Project «Screening of Cardiac Pathology Using Telemedicine Technologies and Elements of Artificial Intelligence» |
No. 03.000.B.163 |
| the Priority 2030 Program of the Ministry of Science and Higher Education of Russia, Project «The Digital Cardiology with Artificial Intelligence» |
No. 03.000.B.166 |
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| Corresponding Author |
Basheer Abdullah Marzoog, MD, PhD, Institute of Personalized Cardiology of The Center “Digital Biodesign and Personalized Healthcare” of Biomedical Science and Technology Park, Sechenov First Moscow State Medical University, 8-2 Trubetskaya Street, Moscow 119991, Moskva, Russia. marzug@mail.ru |
| Key Words |
Ischemic heart disease; Breathome; Aging; Atherosclerosis; Metabolome; Lipidome; Myocardiocytes |
| Core Tip |
This mini-review pioneers a novel integrative concept linking myocardiocyte aging, ischemic heart disease pathogenesis, and the emerging field of breathomics. We propose that the metabolic byproducts of senescent myocardiocytes, released into the bloodstream, are detectable as a unique volatile organic compound signature in exhaled breath. This “breathome” offers a potential non-invasive window to directly assess cardiac biological age and ischemic heart disease status, moving beyond traditional risk scores. The article critically explores this missing chain between cellular senescence and breath biomarkers, framing breath analysis as a future tool for diagnostics, risk stratification, and monitoring of anti-senescence therapies in cardiology. |
| Publish Date |
2026-03-15 06:19 |
| Citation |
Marzoog BA, Kopylov P. Myocardiocyte senescence in ischemic heart disease and breathome changes. World J Exp Med 2026; 16(1): 117186 |
| URL |
https://www.wjgnet.com/2220-315x/full/v16/i1/117186.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v16.i1.117186 |
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