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Articles Published Processes
5/29/2026 7:26:46 AM | Browse: 1 | Download: 15
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Received |
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2025-12-03 02:50 |
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Peer-Review Started |
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2025-12-03 09:27 |
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First Decision by Editorial Office Director |
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2025-12-30 07:50 |
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Return for Revision |
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2025-12-30 07:50 |
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Revised |
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2026-01-30 20:08 |
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Publication Fee Transferred |
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2026-02-02 03:35 |
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Second Decision by Editor |
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2026-03-16 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-17 09:38 |
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Articles in Press |
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2026-03-17 09:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-19 14:21 |
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Publish the Manuscript Online |
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2026-05-29 07:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism of anti-HuD autoantibody inducing enteric neuronal apoptosis of irritable bowel syndrome and its potential for targeted intervention
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Zhang, Chen Zhu, Su-Hong Xia, Ming-Yu Zhang, Yi-Ran Liu, Jia-Lun Guan, Yu-Jie Huang, Kai Zhao, Jia-Zhi Liao and Wen-Juan Fan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82100568 |
| Key Research and Development Program of Hubei Province of China |
2023BCB003 |
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| Corresponding Author |
Wen-Juan Fan, Associate Chief Physician, PhD, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Qiaokou District, Wuhan 430030, Hubei Province, China. juanwenfan1989@tjh.tjmu.edu.cn |
| Key Words |
Irritable bowel syndrome; Anti-HuD autoantibody; Enteric neuron; Apoptosis; Intervention |
| Core Tip |
Current evidence indicates that immune dysregulation contributes to the pathogenesis of irritable bowel syndrome (IBS). However, the direct effects of autoantibodies on the enteric nervous system are unclear. This study established an antibody-mediated IBS model and demonstrated that anti-HuD autoantibodies directly induced enteric neuronal apoptosis by disrupting HuD-mediated RNA regulation. HuD autoantibodies reduced the stability of downstream mRNA and suppressed phosphatidylinositol 3-kinase-protein kinase B signaling, leading to neuronal loss and IBS-like gastrointestinal dysfunction. Pharmacological activation of protein kinase C restored HuD expression and alleviated neuronal apoptosis, highlighting a potential targeted therapeutic strategy for IBS associated with autoimmune-mediated enteric neuropathy. |
| Publish Date |
2026-05-29 07:26 |
| Citation |
Zhang Y, Zhu C, Xia SH, Zhang MY, Liu YR, Guan JL, Huang YJ, Zhao K, Liao JZ, Fan WJ. Mechanism of anti-HuD autoantibody inducing enteric neuronal apoptosis of irritable bowel syndrome and its potential for targeted intervention. World J Gastroenterol 2026; 32(22): 117194 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i22/117194.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i22.117194 |
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