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Articles Published Processes
4/21/2026 9:00:11 AM | Browse: 2 | Download: 10
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Received |
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2025-12-01 05:58 |
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Peer-Review Started |
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2025-12-01 05:58 |
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First Decision by Editorial Office Director |
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2025-12-30 05:49 |
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Return for Revision |
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2025-12-30 15:21 |
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Revised |
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2026-01-05 13:15 |
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Publication Fee Transferred |
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2026-01-09 04:19 |
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Second Decision by Editor |
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2026-02-24 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-24 04:39 |
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Articles in Press |
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2026-02-24 04:39 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-03 07:10 |
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Publish the Manuscript Online |
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2026-04-21 09:00 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Stroma-nerve axis in pancreatic ductal adenocarcinoma: Bidirectional regulatory mechanisms and clinical translation hypothesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Nong Yu, Shui-Quan Jin, Ye-Ting Lu and Lv-Zhou Han |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Provincial Traditional Chinese Medicine Key Specialty Construction Project |
ZJZY[2025]12 |
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| Corresponding Author |
Lv-Zhou Han, Associate Faculty, Deputy Director, Department of Surgery, Yuyao Hospital of Traditional Chinese Medicine, No. 1500 Zhongshan South Road, Yuyao City, Ningbo 315400, Zhejiang Province, China. mm2516406664@gmail.com |
| Key Words |
Pancreatic ductal adenocarcinoma; Tumor microenvironment; Perineural invasion; Cancer-associated fibroblasts; Stroma-nerve axis |
| Core Tip |
We propose the novel “stroma-nerve axis” framework, conceptualizing nerve fibers and stromal components as a functional unit driving pancreatic ductal adenocarcinoma progression. By defining three hypothetical stroma-nerve axis activation subtypes (nerve-dominant, stroma-dominant, and balanced) and a conceptual SNA Activity Score, this review offers a unified theoretical model to explain therapeutic resistance. This perspective shifts the paradigm from single-target interventions to systematic “network dismantling” strategies, providing a roadmap for future stratified clinical trials. |
| Publish Date |
2026-04-21 09:00 |
| Citation |
Yu YN, Jin SQ, Lu YT, Han LZ. Stroma-nerve axis in pancreatic ductal adenocarcinoma: Bidirectional regulatory mechanisms and clinical translation hypothesis. World J Clin Oncol 2026; 17(4): 117197 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i4/117197.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i4.117197 |
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