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Articles Published Processes
6/25/2026 8:21:20 AM | Browse: 0 | Download: 0
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Received |
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2025-12-03 01:03 |
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Peer-Review Started |
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2025-12-03 01:04 |
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First Decision by Editorial Office Director |
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2025-12-16 07:13 |
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Return for Revision |
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2025-12-16 07:13 |
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Revised |
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2025-12-28 08:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-10 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-10 10:29 |
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Articles in Press |
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2026-02-10 10:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-26 09:30 |
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Publish the Manuscript Online |
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2026-06-25 08:21 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Editorial |
| Article Title |
From discarded tissues to therapeutic assets: Optimizing mesenchymal stem cell sources and secretome signatures for clinical translation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Guan-Yu Chen, Jia-Bing Kang, Wen-Jing Xiang and Meng Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Scholarship Council |
202408520036 |
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| Corresponding Author |
Meng Liu, Department of Pediatric Dentistry, Affiliated Stomatological Hospital of Xuzhou Medical University, No. 130 Huaihai West Road, Xuzhou 221000, Jiangsu Province, China. mengliu@xzhmu.edu.cn |
| Key Words |
Oral stem cells; Regenerative medicine; Exosomes; Extracellular vesicles; Secretome; Mesenchymal stem cells |
| Core Tip |
This editorial reframes discarded biological tissues, particularly those from oral and maxillofacial surgery, as valuable regenerative assets rather than medical waste. Drawing on comparative insights from adipose-derived mesenchymal stem cells, we highlight how the neural crest origin of dental mesenchymal stem cells endows them with unique secretome signatures and therapeutic potential. Furthermore, we discuss advanced engineering strategies - such as hypoxic preconditioning, three-dimensional culture, and smart hydrogel delivery - to overcome secretome heterogeneity and facilitate the clinical translation of these cell-free therapies for precision regenerative medicine. |
| Publish Date |
2026-06-25 08:21 |
| Citation |
Chen GY, Kang JB, Xiang WJ, Liu M. From discarded tissues to therapeutic assets: Optimizing mesenchymal stem cell sources and secretome signatures for clinical translation. World J Stem Cells 2026; 18(6): 117267
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i6/117267.htm |
| DOI |
https://doi.org/10.4252/wjsc.117267 |
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