| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Review |
| Article Title |
Future perspectives on mesenchymal stromal cell-derived secretomes in knee osteoarthritis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Anandanarayan Muruganandam, Naveen Jeyaraman, Ashika Mudilikulam Sukumaran, Swaminathan Ramasubramanian, Viji Devanand, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com |
| Key Words |
Bone marrow; Mesenchymal stromal cell; Secretomes; Osteoarthritis; Therapeutics |
| Core Tip |
Mesenchymal stromal cell-derived secretomes, rich in exosomes, cytokines, and growth factors, offer a cell-free therapeutic strategy for knee osteoarthritis by modulating inflammation, promoting chondroprotection, and restoring subchondral bone homeostasis. Their paracrine-driven mechanisms target multiple pathological pathways simultaneously, surpassing symptomatic treatments. However, clinical translation demands rigorous standardization, optimized delivery systems, and clear regulatory frameworks to unlock their full regenerative potential in osteoarthritis management. |
| Publish Date |
2026-04-20 08:05 |
| Citation |
Muruganandam A, Jeyaraman N, Sukumaran AM, Ramasubramanian S, Devanand V, Nallakumarasamy A, Muthu S, Jeyaraman M. Future perspectives on mesenchymal stromal cell-derived secretomes in knee osteoarthritis. World J Stem Cells 2026; 18(4): 117271 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i4/117271.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i4.117271 |
