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Articles Published Processes
2/9/2026 7:34:07 AM | Browse: 1 | Download: 0
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Received |
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2025-12-04 00:39 |
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Peer-Review Started |
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2025-12-04 00:39 |
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First Decision by Editorial Office Director |
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2025-12-12 09:06 |
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Return for Revision |
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2025-12-12 09:06 |
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Revised |
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2025-12-24 02:22 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-14 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-14 09:54 |
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Articles in Press |
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2026-01-14 09:54 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-02 07:36 |
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Publish the Manuscript Online |
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2026-02-09 07:34 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Editorial |
| Article Title |
Mothers against decapentaplegic homolog 4 as a proteomic hub in vascular remodeling and residual cardiovascular risk
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Davide Ramoni, Federico Carbone, Luca Liberale and Fabrizio Montecucco |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fabrizio Montecucco, MD, PhD, Professor, Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, Genoa 16132, Italy. fabrizio.montecucco@unige.it |
| Key Words |
Atherothrombosis; Biomarkers; Endothelial dysfunction; Precision cardiology; Proteomics; Residual cardiovascular risk; Mothers against decapentaplegic homolog 4; Vascular smooth muscle cells |
| Core Tip |
Proteomics is reshaping cardiovascular medicine by revealing network-level molecular mechanisms underlying myocardial infarction and atherothrombosis. Among emerging targets, mothers against decapentaplegic homolog 4 (SMAD4), a central mediator of transforming growth factor-β/bone morphogenetic protein signaling, has gained attention as an interesting regulator linking disturbed flow, inflammation, fibrosis, and vascular remodeling across endothelial and smooth muscle cells. Although not yet supported by large randomized trials, SMAD4 represents a proteomic network hub that may complement established biomarkers such as low-density lipoprotein cholesterol and high-sensitivity C-reactive protein. Integrated within multi-protein signatures and artificial intelligence-based models, SMAD4 may contribute to improved prediction of residual cardiovascular risk and precision phenotyping. |
| Publish Date |
2026-02-09 07:34 |
| Citation |
Ramoni D, Carbone F, Liberale L, Montecucco F. Mothers against decapentaplegic homolog 4 as a proteomic hub in vascular remodeling and residual cardiovascular risk. World J Cardiol 2026; 18(2): 117277 |
| URL |
https://www.wjgnet.com/1949-8462/full/v18/i2/117277.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v18.i2.117277 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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