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5/13/2026 8:18:30 AM | Browse: 6 | Download: 49
Publication Name World Journal of Clinical Pediatrics
Manuscript ID 117283
Country Egypt
Received
2025-12-04 00:41
Peer-Review Started
2025-12-04 00:41
First Decision by Editorial Office Director
2025-12-18 09:26
Return for Revision
2025-12-18 09:26
Revised
2025-12-22 20:56
Publication Fee Transferred
Second Decision by Editor
2026-02-03 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-03 07:13
Articles in Press
2026-02-03 07:13
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-24 00:44
Publish the Manuscript Online
2026-05-13 08:18
ISSN 2219-2808 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Case Control Study
Article Title Circulating levels of growth differentiation factor-15 and its genetic variants -3148C>G (rs4808793) in pediatric cardiac patients
Manuscript Source Invited Manuscript
All Author List Eman Ahmed Abd-Elmawgood, Mohammed H Hassan, Khaled Abdalla Abd-Elbaseer, Mona Hashem Ibrahem, Khaled Mohammed Hassan Yousef and Ali Helmi Bakri
ORCID
Author(s) ORCID Number
Mohammed H Hassan http://orcid.org/0000-0003-2698-9438
Funding Agency and Grant Number
Corresponding Author Mohammed H Hassan, MD, Professor, Department of Medical Biochemistry and Molecular Biology, Faculty of medicine, Qena University, Elsafwa School Street, Qena 83523, Egypt. mohammedhosnyhassaan@yahoo.com
Key Words Growth differentiation factor 15 rs4808793; Pediatric cardiology; Single nucleotide polymorphism; Congenital heart diseases
Core Tip Growth differentiation factor-15 (GDF-15) is increasingly recognized as a valuable biomarker and potential genetic contributor in pediatric cardiac disorders. Significantly elevated serum GDF-15 levels are observed in children with heart failure, reflecting disease severity and progression. Additionally, the higher prevalence of the C-allele of the GDF-15 rs4808793 polymorphism among patients with congenital heart disease supports a genetic susceptibility component. Together, these findings highlight the potential role of GDF-15 in development and progression of pediatric cardiovascular diseases.
Publish Date 2026-05-13 08:18
Citation

Abd-Elmawgood EA, Hassan MH, Abd-Elbaseer KA, Ibrahem MH, Yousef KMH, Bakri AH. Circulating levels of growth differentiation factor-15 and its genetic variants -3148C>G (rs4808793) in pediatric cardiac patients. World J Clin Pediatr 2026; 15(2): 117283

URL https://www.wjgnet.com/2219-2808/full/v15/i2/117283.htm
DOI https://dx.doi.org/10.5409/wjcp.v15.i2.117283
Full Article (PDF) WJCP-15-117283-with-cover.pdf
STROBE Statement 117283-STROBE-statement.pdf
Manuscript File 117283_Auto_Edited_070839.docx
Answering Reviewers 117283-answering-reviewers.pdf
Audio Core Tip 117283-audio.mp3
Biostatistics Review Certificate 117283-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 117283-conflict-of-interest-statement.pdf
Copyright License Agreement 117283-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 117283-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 117283-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 117283-non-native-speakers.pdf
Peer-review Report 117283-peer-reviews.pdf
Scientific Misconduct Check 117283-scientific-misconduct-check.png
Scientific Editor Work List 117283-scientific-editor-work-list.pdf
CrossCheck Report 117283-crosscheck-report.pdf