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Articles Published Processes
6/8/2026 9:12:22 AM | Browse: 3 | Download: 18
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Received |
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2025-12-05 01:31 |
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Peer-Review Started |
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2025-12-05 01:31 |
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First Decision by Editorial Office Director |
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2026-01-07 09:55 |
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Return for Revision |
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2026-01-07 09:55 |
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Revised |
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2026-02-05 16:11 |
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Publication Fee Transferred |
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2026-02-09 04:10 |
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Second Decision by Editor |
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2026-03-12 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-12 08:11 |
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Articles in Press |
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2026-03-12 08:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-26 06:16 |
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Publish the Manuscript Online |
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2026-06-08 09:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Esmolol alleviates lipopolysaccharide-induced intestinal injuries by enhancing autophagy through the AMPK/mTOR/ULK1 pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Bing Zhang, Zhe-Jun Yu, Jun Jin, Mao-Xia Liu, Fu-Hai Ji and Xin-Jing Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82471281 |
| Key Medical Research Projects in Jiangsu Province |
ZD2022021 |
| Key R&D Program Projects in Jiangsu Province |
BE2023709 |
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| Corresponding Author |
Xin-Jing Yang, MD, Department of Intensive Care Unit, The First Affiliated Hospital, Soochow University, No. 188 Shi-Zi Road, Suzhou 215006, Jiangsu Province, China. yangxinjingsuda@163.com |
| Key Words |
Esmolol; AMPK/mTOR/ULK1; Autophagy; Sepsis; Intestinal injury; Lipopolysaccharide |
| Core Tip |
This study investigated the protective effects of esmolol (ES), a selective β1-blocker, against lipopolysaccharide-induced septic intestinal damage. Using both animal and cell models, researchers found that ES pretreatment reduced intestinal injury markers (intestinal fatty acid-binding protein and diamine oxidase), improved tissue damage scores, and suppressed inflammation by suppressing interleukin (IL)-1 tumor necrosis factor-α, IL-17, and IL-6 while enhancing IL-10. Mechanistically, ES enhanced autophagy through activation of the AMPK/mTOR/ULK1 signaling pathway, as shown by increasing the expression of Beclin-1, LC3-II, p-AMPK, p-ULK1 and numbers of autophagosomes, and decreasing the expression of p-mTOR. These effects were consistent in both in vivo and in vitro models. The findings suggest that ES alleviates septic intestinal injury by promoting autophagy via the AMPK/mTOR/ULK1 pathway. |
| Publish Date |
2026-06-08 09:12 |
| Citation |
Zhang YB, Yu ZJ, Jin J, Liu MX, Ji FH, Yang XJ. Esmolol alleviates lipopolysaccharide-induced intestinal injuries by enhancing autophagy through the AMPK/mTOR/ULK1 pathway. World J Gastroenterol 2026; 32(23): 117320
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i23/117320.htm |
| DOI |
https://doi.org/10.3748/wjg.v32.i23.117320 |
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