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Articles Published Processes
5/14/2026 9:17:07 AM | Browse: 6 | Download: 37
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Received |
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2025-12-08 03:34 |
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Peer-Review Started |
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2025-12-08 03:34 |
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First Decision by Editorial Office Director |
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2025-12-24 10:39 |
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Return for Revision |
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2025-12-24 14:23 |
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Revised |
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2025-12-29 12:00 |
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Publication Fee Transferred |
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2026-01-02 10:09 |
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Second Decision by Editor |
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2026-02-11 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-11 05:19 |
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Articles in Press |
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2026-02-11 05:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-27 02:40 |
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Publish the Manuscript Online |
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2026-05-14 09:17 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Metastasis-associated colon cancer 1 drives pancreatic cancer via p53/Notch signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lin Cong, Si Tong, Yu-Jie Xu, De-Yu Zhang, Xiu-Mei Zhang and Hong Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project Foundation of Taizhou School of Clinical Medicine, Nanjing Medical University |
No. TZKY20220205 |
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| Corresponding Author |
Hong Yu, PhD, Department of Pathology, Taizhou People’s Hospital Affiliated to Dalin Medical University, No. 366 Taihu Road, Medical High-tech Zone, Taizhou 225300, Jiangsu Province, China. yuhong@njmu.edu.cn |
| Key Words |
Metastasis-associated colon cancer 1; Pancreatic cancer; P53 pathway; Notch pathway; Multiomics; Tumor progression |
| Core Tip |
Metastasis-associated colon cancer 1 (MACC1) is strongly upregulated in pancreatic cancer (PC) and shows consistent alterations across multiomics datasets. In this study, we combined pan-cancer bioinformatic profiling with functional experiments to clarify its role in PC. Silencing MACC1 suppressed proliferation, migration, invasion, and increased apoptosis, while overexpression produced the opposite effects. We also confirmed that MACC1 activates both p53 and Notch signaling. These findings show that MACC1 is not only a useful diagnostic and prognostic marker but also a potential therapeutic target in PC. |
| Publish Date |
2026-05-14 09:17 |
| Citation |
Cong L, Tong S, Xu YJ, Zhang DY, Zhang XM, Yu H. Metastasis-associated colon cancer 1 drives pancreatic cancer via p53/Notch signaling. World J Gastrointest Oncol 2026; 18(5): 117323 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i5/117323.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i5.117323 |
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