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Articles Published Processes
9/9/2026 9:45:18 AM | Browse: 2 | Download: 0
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Received |
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2025-12-05 00:19 |
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Peer-Review Started |
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2025-12-05 08:32 |
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First Decision by Editorial Office Director |
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2025-12-17 08:04 |
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Return for Revision |
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2025-12-17 08:04 |
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Revised |
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2025-12-21 07:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-05 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-06 00:11 |
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Articles in Press |
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2026-01-06 00:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-20 08:09 |
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Publish the Manuscript Online |
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2026-09-09 09:45 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Citrullinated matrisome: An emerging stromal determinant in hepatocellular carcinoma prognostication
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhi-Feng Xu, Yu-Ru Yao, Shen-Yi Ye and Cheng-Fei Zhao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Project of Putian University |
2022059 |
| Special Project for Outstanding Young Talents of Putian University |
2024072 |
| Natural Science Foundation of Fujian Province |
2023J01160 |
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| Corresponding Author |
Cheng-Fei Zhao, Associate Professor, MD, PhD, School of Pharmacy and Medical Technology, Putian University, Department of Pharmacy, School of Pharmacy and Medical Technology, Putian University, 1133 Xueyuan Road, Chengxiang District, Putian 351100, China, Putian 351100, Fujian Province, China. zhaochengfei209@163.com |
| Key Words |
Hepatocellular carcinoma; Tumor microenvironment; Citrullination; Glial fibrillary acidic protein; Biomarker; Prognosis; Hepatic stellate cells; Extracellular matrix |
| Core Tip |
This editorial highlights the groundbreaking study by Cho et al. that identifies citrullinated glial fibrillary acidic protein (cit-GFAP) as a novel stromal biomarker in hepatocellular carcinoma (HCC). The study shifts the prognostic focus from the tumor cell per se to the post-translationally modified extracellular matrix, demonstrating that elevated cit-GFAP expression is an independent predictor of poor survival following curative resection. We discuss how these findings underscore the critical role of post-translational modifications within the tumor microenvironment and propose a future research agenda for the validation of cit-GFAP and the exploration of peptidylarginine deiminase inhibition as a potential therapeutic strategy in HCC. |
| Publish Date |
2026-09-09 09:45 |
| Citation |
Xu ZF, Yao YR, Ye SY, Zhao CF. Citrullinated matrisome: An emerging stromal determinant in hepatocellular carcinoma prognostication. World J Gastrointest Oncol 2026; 18(9): 117335
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i9/117335.htm |
| DOI |
https://doi.org/10.4251/wjgo.117335 |
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