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Articles Published Processes
5/29/2026 8:41:37 AM | Browse: 1 | Download: 12
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Received |
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2025-12-05 00:45 |
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Peer-Review Started |
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2025-12-05 00:45 |
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First Decision by Editorial Office Director |
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2026-01-08 09:18 |
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Return for Revision |
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2026-01-08 09:18 |
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Revised |
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2026-02-09 20:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-02 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-02 04:02 |
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Articles in Press |
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2026-04-02 04:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-18 04:01 |
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Publish the Manuscript Online |
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2026-05-29 08:41 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Review |
| Article Title |
Immunosenescence and cancer predisposition in pediatric transplant recipients: An emerging paradigm
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aya Mohamed Adel Arafat, Soliman M A Soliman, Habiba Elfandy, Moamen O Othman, Walaa Elsayed, Mai M Lotfy and Noura A A Ebrahim |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Noura A A Ebrahim, Department of Oncologic Pathology, National Cancer Institute, Cairo University, 1st El Kasr El Aini Street, Cairo 11796, Egypt. npathologist@gmail.com |
| Key Words |
Immunosenescence; Pediatric transplantation; Cancer predisposition; T cell exhaustion; Post-transplant lymphoproliferative disease; Cytomegalovirus; Telomere dysfunction; Thymic involution; Inflammaging; Senescence-associated secretory phenotype |
| Core Tip |
Children who undergo organ transplantation often experience premature aging of the immune system, largely due to factors such as ATG exposure, CMV reactivation, thymic dysfunction, and long-term immunosuppressive therapy. This accelerated immune decline substantially increases their risk of developing cancer both early and later in life. Adopting a biomarker-driven clinical approach—including senescence-related flow cytometry panels, TREC/telomere assessments, and epigenetic aging markers—along with tailored immunosuppression strategies, vigilant CMV management, and emerging therapies targeting senescent, thymic, or metabolic pathways may help lessen cancer risk and improve long-term patient outcomes. |
| Publish Date |
2026-05-29 08:41 |
| Citation |
Arafat AMA, Soliman SMA, Elfandy H, Othman MO, Elsayed W, Lotfy MM, Ebrahim NAA. Immunosenescence and cancer predisposition in pediatric transplant recipients: An emerging paradigm. World J Transplant 2026; 16(2): 117357 |
| URL |
https://www.wjgnet.com/2220-3230/full/v16/i2/117357.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v16.i2.117357 |
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