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Articles Published Processes
8/18/2026 3:51:57 AM | Browse: 1 | Download: 0
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Received |
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2025-12-08 00:49 |
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Peer-Review Started |
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2025-12-08 00:49 |
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First Decision by Editorial Office Director |
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2025-12-16 10:06 |
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Return for Revision |
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2025-12-17 09:27 |
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Revised |
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2025-12-25 09:57 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-05 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-05 09:54 |
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Articles in Press |
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2026-02-05 09:54 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-11 00:39 |
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Publish the Manuscript Online |
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2026-08-18 03:51 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Natural product intervention in metabolic dysfunction-associated steatotic liver disease: From allyl isothiocyanate to signaling networks
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rui Tian, Yi-Xin Wu, Jie-Yu Guo, Xing-Zhen Chen, Jing-Feng Tang and Ce-Fan Zhou |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ce-Fan Zhou, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn |
| Key Words |
Allyl isothiocyanate; Metabolically-dysfunction-associated steatotic liver disease; Vitamin D receptor; Multitarget therapy; Network pharmacology |
| Core Tip |
This comment highlights that allyl isothiocyanate (AITC) illustrates the principle of multi-target natural product therapy for metabolic dysfunction-associated steatotic liver disease. Beyond the novel vitamin D receptor/hepatocyte nuclear factor 4 alpha pathway identified by Gao et al, we integrate this axis with established AITC targets, such as sirtuin 1/AMP-activated protein kinase, nuclear factor erythroid 2-related factor 2, to construct a multiple-signaling network. This network collectively reprograms lipid metabolism, insulin sensitivity, and oxidative stress. Future research must validate this integrative mechanism in vivo and leverage systems biology to advance AITC as a precise, network-based therapeutic strategy. |
| Publish Date |
2026-08-18 03:51 |
| Citation |
Tian R, Wu YX, Guo JY, Chen XZ, Tang JF, Zhou CF. Letter to the Editor: Natural product intervention in metabolic dysfunction-associated steatotic liver disease: From allyl isothiocyanate to signaling networks. World J Hepatol 2026; 18(8): 117382
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i8/117382.htm |
| DOI |
https://doi.org/10.4254/wjh.117382 |
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