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Articles Published Processes
4/3/2026 6:41:52 AM | Browse: 0 | Download: 0
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Received |
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2025-12-08 02:13 |
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Peer-Review Started |
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2025-12-08 09:27 |
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First Decision by Editorial Office Director |
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2025-12-18 10:05 |
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Return for Revision |
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2025-12-18 10:05 |
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Revised |
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2025-12-29 13:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-27 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-27 08:15 |
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Articles in Press |
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2026-01-27 08:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-27 02:16 |
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Publish the Manuscript Online |
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2026-04-03 06:41 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Roles of hepatic immunity in metabolic dysfunction-associated steatotic liver disease: Cellular and molecular mechanisms and clinical trials
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming Yang, Olamide T Olaoba, Stephanie C Chinwo, Hannah LeVasseur, Beiyan Zhou, Eric T Kimchi, Kevin F Staveley-O’Carroll and Guangfu Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
No. R01DK130340 |
| National Institutes of Health |
No. R01CA274959 |
| National Institutes of Health |
No. R01CA250536 |
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| Corresponding Author |
Guangfu Li, PhD, Professor, Department of Surgery, School of Medicine, University of Connecticut, 263 Farmington Avenue, Farmington, CT 06030, United States. gli@uchc.edu |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Innate immune cells; Molecular mechanisms; Clinical trials; Drugs |
| Core Tip |
Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a broad spectrum of pathology ranging from hepatic steatosis to metabolic dysfunction-associated steatohepatitis (MASH). Effective treatments for MASLD remain limited. Hepatic innate immune cells play an essential role in maintaining liver physiological homeostasis and contributing to MASLD pathogenesis and progression by interacting with liver parenchymal cells and adaptive immune cells in the progression of MASLD and MASH. Treatments targeting innate immune cell manipulation and metabolic modulation, such as fibroblast growth factor 21 analogues, farnesoid X receptor agonists, and chemokine receptor antagonists, can provide therapeutic strategies for MASLD. |
| Publish Date |
2026-04-03 06:41 |
| Citation |
Yang M, Olaoba OT, Chinwo SC, LeVasseur H, Zhou B, Kimchi ET, Staveley-O’Carroll KF, Li G. Roles of hepatic immunity in metabolic dysfunction-associated steatotic liver disease: Cellular and molecular mechanisms and clinical trials. World J Gastroenterol 2026; 32(14): 117396 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i14/117396.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i14.117396 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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