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Articles Published Processes
7/24/2026 7:03:47 AM | Browse: 1 | Download: 0
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Received |
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2025-12-08 00:55 |
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Peer-Review Started |
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2025-12-08 00:55 |
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First Decision by Editorial Office Director |
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2025-12-31 08:26 |
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Return for Revision |
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2025-12-31 08:26 |
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Revised |
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2026-02-05 22:01 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-24 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-24 06:10 |
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Articles in Press |
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2026-04-24 06:10 |
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Edit the Manuscript by Language Editor |
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2026-04-28 23:43 |
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Typeset the Manuscript |
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2026-07-15 08:13 |
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Publish the Manuscript Online |
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2026-07-24 07:03 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Immune-transcriptomic profiles in peripheral blood mononuclear cells highlight early dysregulation in adolescent non-alcoholic fatty liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Noura A A Ebrahim, Aya Arafat and Soliman M A Soliman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Noura A A Ebrahim, Department of Oncologic Pathology, National Cancer Institute, Cairo University, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com |
| Key Words |
Adolescent non-alcoholic fatty liver disease; Peripheral blood mononuclear cells; Immune dysregulation; Gut-liver axis; Transcriptomic profiling |
| Core Tip |
This letter underscores the early immune disturbances in adolescents with non-alcoholic fatty liver disease (NAFLD) revealed through transcriptomic and cytokine analysis of peripheral blood mononuclear cells (PBMCs). By exposing PBMCs to autologous fecal extracts, the study recreates gut-liver interactions in vitro, highlighting how host-specific microbiota shape systemic immune responses. These results suggest that PBMC-derived immune signatures could serve as minimally invasive biomarkers and inform the development of personalized diagnostic and therapeutic strategies in pediatric NAFLD. |
| Publish Date |
2026-07-24 07:03 |
| Citation |
Ebrahim NAA, Arafat A, Soliman SMA. Letter to the Editor: Immune-transcriptomic profiles in peripheral blood mononuclear cells highlight early dysregulation in adolescent non-alcoholic fatty liver disease. World J Hepatol 2026; 18(7): 117406
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i7/117406.htm |
| DOI |
https://doi.org/10.4254/wjh.117406 |
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