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8/4/2026 7:19:47 AM | Browse: 0 | Download: 0
Publication Name World Journal of Gastroenterology
Manuscript ID 117409
Country China
Received
2025-12-08 02:32
Peer-Review Started
2025-12-08 02:32
First Decision by Editorial Office Director
2026-01-08 09:29
Return for Revision
2026-01-08 09:29
Revised
2026-01-09 06:39
Publication Fee Transferred
Second Decision by Editor
2026-01-21 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-21 08:17
Articles in Press
2026-01-21 08:17
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-12 14:45
Publish the Manuscript Online
2026-08-04 07:19
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title AI Morphology and Host Complexity for Precision Prediction of Nodal Metastasis in Colorectal Cancer
Manuscript Source Invited Manuscript
All Author List Gang Wang and Sheng-Jie Pan
ORCID
Author(s) ORCID Number
Gang Wang http://orcid.org/0009-0009-8864-7688
Funding Agency and Grant Number
Corresponding Author Gang Wang, MD, PhD, Professor, Department of General Surgery, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou City Jiangsu Province, China, Suzhou 215006, Jiangsu Province, China. 286651551@qq.com
Key Words Artificial intelligence; Deep learning; Computational pathology; Multiple instance learning; Colorectal cancer; Lymph node metastasis; Tumor microenvironment; Systemic inflammation; Physiologic complexity; Precision surgical oncology
Core Tip This Editorial highlights how a case-level multiple instance learning approach can reveal morphologic patterns predictive of lymph node metastasis in colorectal cancer. Yet morphology alone is insufficient. Integrating artificial intelligence–derived histology with systemic host factors—including inflammation, metabolic reserve, autonomic balance, and physiologic complexity—offers a more biologically coherent foundation for risk stratification and precision surgical decision-making.
Publish Date 2026-08-04 07:19
Citation

Wang G, Pan SJ. AI Morphology and Host Complexity for Precision Prediction of Nodal Metastasis in Colorectal Cancer. World J Gastroenterol 2026; 32(31): 117409

URL https://www.wjgnet.com/1007-9327/full/v32/i31/117409.htm
DOI https://doi.org/10.3748/wjg.117409
Full Article (PDF) WJG-32-117409-with-cover.pdf
Manuscript File 117409_Auto_Edited_040316.docx
Answering Reviewers 117409-answering-reviewers.pdf
Audio Core Tip 117409-audio.mp3
Conflict-of-Interest Disclosure Form 117409-conflict-of-interest-statement.pdf
Copyright License Agreement 117409-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 117409-non-native-speakers.pdf
Peer-review Report 117409-peer-reviews.pdf
Scientific Misconduct Check 117409-scientific-misconduct-check.png
Scientific Editor Work List 117409-scientific-editor-work-list.pdf
CrossCheck Report 117409-crosscheck-report.pdf