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Articles Published Processes
8/3/2026 1:23:49 AM | Browse: 2 | Download: 0
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Received |
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2025-12-08 02:49 |
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Peer-Review Started |
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2025-12-08 02:50 |
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First Decision by Editorial Office Director |
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2025-12-24 09:44 |
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Return for Revision |
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2025-12-24 09:44 |
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Revised |
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2025-12-24 17:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-17 03:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-17 04:23 |
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Articles in Press |
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2026-03-17 04:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-20 00:20 |
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Publish the Manuscript Online |
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2026-08-03 01:23 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Review |
| Article Title |
From genes to environment: A life-course approach to prevent pediatric autoimmune diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mohammed Al-Beltagi, Nermin K Saeed, Adel S Bediwy, Eman A Bediwy and Reem Elbeltagi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mohammed Al-Beltagi, Chairman, Consultant, Full Professor, MD, PhD, Senior Researcher, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mohamed.elbeltagi@med.tanta.edu.eg |
| Key Words |
Pediatric autoimmunity; Children; Precision prevention; Microbiome; Teplizumab; Immunomodulation; Primary prevention; Exposome |
| Core Tip |
The rising global incidence of pediatric autoimmune diseases necessitates a strategic shift from reactive disease management to proactive prevention. This article outlines a comprehensive, integrated framework that leverages advances in genomics and exposomics to identify and intervene in high-risk children. The model begins with primordial prevention during the first 1000 days, progressing through primary and secondary interventions, and concluding with aggressive therapy for established disease. By adopting this tiered approach, clinicians, researchers, and public health officials can work collaboratively to alter disease trajectories, reduce the long-term burden of these conditions, and ultimately improve the health outcomes for future generations. |
| Publish Date |
2026-08-03 01:23 |
| Citation |
Al-Beltagi M, Saeed NK, Bediwy AS, Bediwy EA, Elbeltagi R. From genes to environment: A life-course approach to prevent pediatric autoimmune diseases. World J Clin Pediatr 2026; 15(9): 117421
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| URL |
https://www.wjgnet.com/2219-2808/full/v15/i3/117421.htm |
| DOI |
https://doi.org/10.5409/wjcp.117421 |
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