| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Migration and repair of intestinal mucosal cells in pancreas-intestine anastomosis via inflammatory mediators: A beagle study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Xing Wu, Paerhatijiang Abulimiti, Bo-Lin Zhang, Atigu Abuduwaili, Cheng Wang, Jian-Gang Li, Yindala Ba, Dilixiati Tuniyazi, Cheng Geng and Xin-Jian Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82160491 |
| Tianshan Talent Project of Xinjiang Uygur Autonomous Region |
No. TSYC202301A036 |
|
| Corresponding Author |
Xin-Jian Xu, Chief, MD, Professor, Department of Hepatobiliary and Pancreatic Surgery, Fifth Affiliated Hospital of Xinjiang Medical University, No. 118 Henan West Road, Xinshi District, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. xxj10101@163.com |
| Key Words |
Pancreaticoduodenectomy; Pancreaticojejunostomy; Pancreatic fistula; Inflammatory mediators; Wound healing; Intestinal mucosal cells; Animal research; Interleukin-6; Interleukin-10; Transforming growth factor-β |
| Core Tip |
This study investigates the migration of intestinal mucosal cells and the role of inflammatory mediators in pancreaticojejunal anastomosis using a beagle model. The novel pancreaticojejunostomy with mucosal-priority healing technique demonstrates a lower incidence of anastomotic leakage and reduced postoperative complications. Elevated levels of transforming growth factor-β1 and interleukin-6 are observed, indicating their critical role in early healing through collagen synthesis. These findings highlight the benefits of prioritizing mucosal healing and offer insights into optimizing surgical techniques for improved clinical outcomes. |
| Publish Date |
2026-04-24 10:11 |
| Citation |
Wu SX, Abulimiti P, Zhang BL, Abuduwaili A, Wang C, Li JG, Ba Y, Tuniyazi D, Geng C, Xu XJ. Migration and repair of intestinal mucosal cells in pancreas-intestine anastomosis via inflammatory mediators: A beagle study. World J Gastrointest Surg 2026; 18(4): 117422 |
| URL |
https://www.wjgnet.com/1948-9366/full/v18/i4/117422.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v18.i4.117422 |
