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3/5/2026 7:45:14 AM | Browse: 5 | Download: 13
Publication Name World Journal of Clinical Cases
Manuscript ID 117431
Country India
Received
2025-12-08 02:53
Peer-Review Started
2025-12-08 02:53
First Decision by Editorial Office Director
2025-12-31 07:52
Return for Revision
2025-12-31 07:52
Revised
2026-01-13 20:57
Publication Fee Transferred
Second Decision by Editor
2026-02-02 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-02 09:48
Articles in Press
2026-02-02 09:48
Edit the Manuscript by Language Editor
2026-02-08 00:15
Typeset the Manuscript
2026-02-11 06:58
Publish the Manuscript Online
2026-03-05 07:45
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Combined anticoagulant deficiency causing extrahepatic portal venous obstruction: A case report
Manuscript Source Invited Manuscript
All Author List Arkadeep Dhali, Rick Maity, Arijit Sinha, Prithviraj Singh, Jyotirmoy Biswas and Gopal Krishna Dhali
ORCID
Author(s) ORCID Number
Arkadeep Dhali http://orcid.org/0000-0002-1794-2569
Rick Maity http://orcid.org/0009-0003-5316-2329
Gopal Krishna Dhali http://orcid.org/0000-0002-6759-5067
Funding Agency and Grant Number
Corresponding Author Rick Maity, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Ardeshir Dalal Avenue, Kharagpur 721302, India. rickmaity98@gmail.com
Key Words Extrahepatic portal venous obstruction; Portal vein; Portal vein thrombosis; Protein S deficiency; Protein C deficiency; Antithrombin III deficiency; Case Report
Core Tip Extrahepatic portal venous obstruction (EHPVO) is a leading cause of non-cirrhotic portal hypertension in young individuals. It is linked to procoagulable states; however, combined anticoagulant deficiencies are rare. This case describes a 27-year-old adult with long-standing EHPVO complicated by recurrent thrombotic and hemorrhagic events in the setting of combined deficiencies of protein S, protein C, and antithrombin III. It highlights the diagnostic uncertainty in distinguishing between acquired and inherited anticoagulant deficiencies in chronic portal vein thrombosis and underscores the clinical challenge of balancing anticoagulation against the risk of bleeding in EHPVO.
Publish Date 2026-03-05 07:45
Citation

Dhali A, Maity R, Sinha A, Singh P, Biswas J, Dhali GK. Combined anticoagulant deficiency causing extrahepatic portal venous obstruction: A case report. World J Clin Cases 2026; 14(7): 117431

URL https://www.wjgnet.com/2307-8960/full/v14/i7/117431.htm
DOI https://dx.doi.org/10.12998/wjcc.v14.i7.117431
Full Article (PDF) WJCC-14-117431-with-cover.pdf
CARE Checklist–2016 117431-CARE-Checklist-2016.pdf
Manuscript File 117431_Auto_Edited_073822.docx
Answering Reviewers 117431-answering-reviewers.pdf
Audio Core Tip 117431-audio.mp3
Conflict-of-Interest Disclosure Form 117431-conflict-of-interest-statement.pdf
Copyright License Agreement 117431-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 117431-informed-consent-statement.pdf
Peer-review Report 117431-peer-reviews.pdf
Scientific Misconduct Check 117431-scientific-misconduct-check.png
Scientific Editor Work List 117431-scientific-editor-work-list.pdf
CrossCheck Report 117431-crosscheck-report.pdf