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Publication Name World Journal of Hepatology
Manuscript ID 117441
Country Egypt
Received
2025-12-08 03:46
Peer-Review Started
2025-12-08 03:46
First Decision by Editorial Office Director
2025-12-25 08:24
Return for Revision
2025-12-25 08:24
Revised
2026-01-07 13:08
Publication Fee Transferred
2026-01-09 16:19
Second Decision by Editor
2026-02-11 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-11 09:38
Articles in Press
2026-02-11 09:38
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-03-30 14:21
Publish the Manuscript Online
2026-05-26 03:52
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging
Manuscript Source Unsolicited Manuscript
All Author List Amany Sholkamy, Ahmed El-Meligui, Eman H Saad, Samar Amin, Mirette Makram, Noha Elmansy and Shrook Mousa
ORCID
Author(s) ORCID Number
Amany Sholkamy http://orcid.org/0000-0001-5914-869X
Ahmed El-Meligui http://orcid.org/0000-0002-3117-5837
Eman H Saad http://orcid.org/0000-0002-4526-4128
Samar Amin http://orcid.org/0009-0004-0081-0553
Mirette Makram http://orcid.org/0009-0003-7328-0824
Noha Elmansy http://orcid.org/0000-0001-5794-5046
Shrook Mousa http://orcid.org/0000-0002-9720-8240
Funding Agency and Grant Number
Corresponding Author Mirette Makram, Consultant, MD, Department of Endocrinology Section, Department of Internal Medicine, Kasralainy Hospitals, Cairo University, 1 Gamaa Street, Giza, Cairo 12613, Al Qāhirah, Egypt. mirettemakram@kasralainy.edu.eg
Key Words Metabolic dysfunction-associated steatotic liver disease; Hypothyroidism; Overt; Subclinical; Predictors; Fibrosis; Severity; Ultrasonography; Magnetic resonance imaging
Core Tip Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the foremost etiology of cirrhosis and hepatocellular carcinoma. Our study assessed the overlooked association between this global liver disease and the spectrum of hypothyroidism. The three study groups (overt, subclinical hypothyroid, control) were assessed for MASLD by ultrasonography. The diagnosis was confirmed by magnetic resonance imaging, hepatic fat percentage was calculated. Ultrasound results were compared with magnetic resonance imaging findings to determine degree of agreement between both diagnostic methods. Multivariate analysis identified the independent risk variables associated with the onset and severeness of MASLD. The receiver operating characteristic curve concluded that there is a certain thyroid-stimulating hormone level above which the risk of MASLD development increases.
Publish Date 2026-05-26 03:52
Citation

Sholkamy A, El-Meligui A, H Saad E, Amin S, Makram M, Elmansy N, Mousa S. Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging. World J Hepatol 2026; 18(5): 117441

URL https://www.wjgnet.com/1948-5182/full/v18/i5/117441.htm
DOI https://dx.doi.org/10.4254/wjh.v18.i5.117441
Full Article (PDF) WJH-18-117441-with-cover.pdf
STROBE Statement 117441-STROBE-statement.pdf
Manuscript File 117441_Auto_Edited_065525.docx
Answering Reviewers 117441-answering-reviewers.pdf
Audio Core Tip 117441-audio.mpeg
Biostatistics Review Certificate 117441-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 117441-conflict-of-interest-statement.pdf
Copyright License Agreement 117441-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 117441-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 117441-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 117441-non-native-speakers.pdf
Peer-review Report 117441-peer-reviews.pdf
Scientific Misconduct Check 117441-scientific-misconduct-check.png
Scientific Editor Work List 117441-scientific-editor-work-list.pdf
CrossCheck Report 117441-crosscheck-report.pdf