| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Novel nomogram for differential diagnosis of UGT1A1 gene mutation-associated unconjugated hyperbilirubinemia with hemolytic diseases
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Tian Yu, Mei-Han Li, Shan Tang, Chen Liang, Da-Cheng Sheng, Hui Jiang, Jian-Xia Dong, Wei Hou and Su-Jun Zheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Key Research and Development Program of Ministry of Science and Technology |
2022YFC2304400 |
| Beijing Hospitals Authority’s Ascent Plan |
DFL20241701 |
| High-Level Public Health Technical Talents of the Beijing Municipal Health Commission |
Academic Leader-02-14 |
|
| Corresponding Author |
Su-Jun Zheng, MD, PhD, Department of Hepatology, Beijing YouAn Hospital, Capital Medical University, No. 8 Xitoutiao, Youwai Street, Beijing 100069, China. zhengsujun@ccmu.edu.cn |
| Key Words |
Hyperbilirubinemia; Gilbert’s syndrome; Hemolysis; Diagnosis; Nomogram |
| Core Tip |
Clinical characteristic overlap and the need for complex specialized testing make it challenging to distinguish uridine diphosphate glucuronosyltransferase 1A1 mutations from hemolytic diseases in patients with chronic unconjugated hyperbilirubinemia. In a genetically confirmed cohort, we applied least absolute shrinkage and selection operator and logistic regression to identify four variables for differential diagnosis: Abnormal peripheral blood smear, hematocrit, red cell distribution width standard deviation, and reticulocyte percentage. These variables were used to establish a nomogram model, which achieved an area under the receiver operating characteristic of 0.986 and an area under precision-recall curve of 0.938. This model provides a simple, interpretable, and cost-effective tool for early screening and triage, potentially reducing the need for complex testing. |
| Publish Date |
2026-04-21 08:57 |
| Citation |
Yu HT, Li MH, Tang S, Liang C, Sheng DC, Jiang H, Dong JX, Hou W, Zheng SJ. Novel nomogram for differential diagnosis of UGT1A1 gene mutation-associated unconjugated hyperbilirubinemia with hemolytic diseases. World J Hepatol 2026; 18(4): 117456 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i4/117456.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i4.117456 |
