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Articles Published Processes
5/14/2026 9:17:09 AM | Browse: 1 | Download: 0
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Received |
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2025-12-09 01:12 |
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Peer-Review Started |
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2025-12-09 01:12 |
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First Decision by Editorial Office Director |
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2026-01-07 09:56 |
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Return for Revision |
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2026-01-08 07:08 |
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Revised |
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2026-01-16 13:36 |
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Publication Fee Transferred |
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2026-01-20 08:26 |
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Second Decision by Editor |
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2026-02-10 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-10 07:06 |
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Articles in Press |
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2026-02-10 07:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-28 00:15 |
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Publish the Manuscript Online |
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2026-05-14 09:17 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Baseline and longitudinal biomarkers predict hepatocellular carcinoma in chronic hepatitis C: A cohort study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Lin Li, Hung-Da Tung, Tang-Wei Chuang, Chun-Ta Cheng, Mai-Gio Pang, Jyh-Jou Chen, Kun-Ming Zhong, Ting-Yi Huang and Pei-Lun Lee |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Pei-Lun Lee, Chief Physician, Lecturer, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, No 201 Taikang, Liuying District, Tainan City, 736, Taiwan., Tainan 736402, Taiwan. peilun57@gmail.com |
| Key Words |
Chronic hepatitis C; Hepatocellular carcinoma; Fibrosis-4 index; Alpha-fetoprotein; Longitudinal biomarkers; Risk stratification; Cohort study |
| Core Tip |
This retrospective cohort study evaluated 271 treatment-naïve patients with chronic hepatitis C to determine whether baseline and 3-year trajectories of the fibrosis-4 (FIB-4) index and other biomarkers predict long-term hepatocellular carcinoma (HCC) risk. A baseline FIB-4 value > 3.25 strongly predicted HCC independently, while a 3-year ΔFIB-4 ≥ 1 helped risk stratification. Persistently low FIB-4 values identified a group with negligible HCC incidence. Periodic, low-cost monitoring of FIB-4 and alpha-fetoprotein may offer a practical approach to guide surveillance and treatment prioritization in resource-limited settings. |
| Publish Date |
2026-05-14 09:17 |
| Citation |
Li YL, Tung HD, Chuang TW, Cheng CT, Pang MG, Chen JJ, Zhong KM, Huang TY, Lee PL. Baseline and longitudinal biomarkers predict hepatocellular carcinoma in chronic hepatitis C: A cohort study. World J Gastrointest Oncol 2026; 18(5): 117512 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i5/117512.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i5.117512 |
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