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Articles Published Processes
6/11/2026 11:23:55 AM | Browse: 0 | Download: 0
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Received |
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2025-12-12 00:12 |
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Peer-Review Started |
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2025-12-14 15:20 |
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First Decision by Editorial Office Director |
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2026-02-03 08:26 |
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Return for Revision |
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2026-02-03 08:26 |
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Revised |
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2026-02-16 07:36 |
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Publication Fee Transferred |
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2026-02-22 07:04 |
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Second Decision by Editor |
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2026-04-08 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-08 06:54 |
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Articles in Press |
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2026-04-08 06:54 |
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Edit the Manuscript by Language Editor |
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2026-04-15 00:01 |
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Typeset the Manuscript |
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2026-06-03 11:03 |
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Publish the Manuscript Online |
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2026-06-11 11:23 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Shenqi Jiangtang Granules attenuate ferroptosis in diabetic cardiomyopathy via the dihydroorotate dehydrogenase-coenzyme Q pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Ting Tang, Yu-Peng Chen, Ya-Nan Yang, Jun-Li Liu, Qian Wu, Shan Zhang, Qing Pang, Mao-Ying Wei, Yan-Bing Gong and Qing Ni |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation |
GZC20230324 |
| China Postdoctoral Science Foundation |
2024M750263 |
| the Leading Talent Training Program Project of Dongzhimen Hospital, Beijing University of Chinese Medicine |
DZMG-LJRC0004 |
| the Fundamental Research Funds for the Central Universities |
2023-JYB-JBZD-010 |
| the High-Level Chinese Medical Hospital Promotion Project |
HLCMHPP2023084 |
| the National Key R&D Program of China |
2024ZD0523503 |
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| Corresponding Author |
Qing Ni, Professor, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5, Beixiange, Xicheng District, Beijing 100053, China. niqing2834@gamyy.cn |
| Key Words |
Shenqi Jiangtang Granules; Diabetic cardiomyopathy; Ferroptosis; DHODH/CoQ pathway; Oxidative stress |
| Core Tip |
This study investigates the mechanisms of Shenqi Jiangtang Granules (SQJT) against diabetic cardiomyopathy (DCM). By integrating network pharmacology and experimental validation, we identified dihydroorotate dehydrogenase (DHODH) as a key therapeutic target. We demonstrate that SQJT mitigates ferroptosis and mitochondrial injury in H9C2 cardiomyocytes by activating the DHODH/coenzyme Q axis. These protective effects are significantly abolished by DHODH inhibition. This research provides mechanistic evidence that SQJT exerts cardioprotective effects through ferroptosis regulation, and highlights its potential as a therapeutic strategy for mitochondrial dysfunction in DCM. |
| Publish Date |
2026-06-11 11:23 |
| Citation |
Tang YT, Chen YP, Yang YN, Liu JL, Wu Q, Zhang S, Pang Q, Wei MY, Gong YB, Ni Q. Shenqi Jiangtang Granules attenuate ferroptosis in diabetic cardiomyopathy via the dihydroorotate dehydrogenase-coenzyme Q pathway. World J Diabetes 2026; 17(6): 117524
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i6/117524.htm |
| DOI |
https://doi.org/10.4239/wjd.117524 |
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