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Articles Published Processes
4/21/2026 9:00:11 AM | Browse: 24 | Download: 36
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Received |
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2025-12-10 01:45 |
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Peer-Review Started |
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2025-12-10 05:37 |
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First Decision by Editorial Office Director |
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2025-12-25 08:20 |
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Return for Revision |
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2025-12-25 08:20 |
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Revised |
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2026-01-06 09:06 |
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Publication Fee Transferred |
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2026-01-10 09:52 |
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Second Decision by Editor |
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2026-02-10 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-10 10:39 |
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Articles in Press |
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2026-02-10 10:39 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-03 07:10 |
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Publish the Manuscript Online |
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2026-04-21 09:00 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Minireviews |
| Article Title |
Precision therapy for driver gene mutations in breast cancer: Current landscape and future perspectives
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Yong Liu and Ran Chen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhi-Yong Liu, Breast Diagnosis and Treatment Center, First Affiliated Hospital of Gannan Medical University, No. 128 Jinling Road, Huangjin Technology Development Zone, Ganzhou 341000, Jiangxi Province, China. barton123321@163.com |
| Key Words |
Breast cancer; Driver gene mutation; Precision therapy; Targeted therapy; Next-generation sequencing |
| Core Tip |
This article delineates the paradigm of driver gene mutation-guided precision therapy in breast cancer. We synthesize the clinical application of targeting key mutations (e.g., PIK3CA, ESR1, BRCA1/2) and analyze the complex landscape of acquired resistance. Critically, we propose a forward-looking framework integrating multi-omics, liquid biopsy, and artificial intelligence to dynamically navigate treatment. The article underscores the necessity of evolving from static biomarker testing towards a proactive, digitally-enabled ecosystem to overcome resistance and optimize sequential therapy, ultimately aiming for sustained patient benefit. |
| Publish Date |
2026-04-21 09:00 |
| Citation |
Liu ZY, Chen R. Precision therapy for driver gene mutations in breast cancer: Current landscape and future perspectives. World J Clin Oncol 2026; 17(4): 117540 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i4/117540.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i4.117540 |
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