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Publication Name World Journal of Diabetes
Manuscript ID 117542
Country China
Received
2025-12-10 00:44
Peer-Review Started
2025-12-10 08:31
First Decision by Editorial Office Director
2026-01-06 06:35
Return for Revision
2026-01-06 06:35
Revised
2026-01-17 12:48
Publication Fee Transferred
Second Decision by Editor
2026-02-06 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-06 08:56
Articles in Press
2026-02-06 08:56
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-03 15:30
Publish the Manuscript Online
2026-06-11 11:23
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Correspondence
Article Title Letter to the Editor: Akkermansia muciniphila serves as an immunomodulator for type 1 diabetes mellitus: Promises and pitfalls
Manuscript Source Invited Manuscript
All Author List Ying Qian, Jun Xu, Jun-Min Wang, Xing-Li Wu and Yi-Yuan Zheng
ORCID
Author(s) ORCID Number
Yi-Yuan Zheng http://orcid.org/0000-0001-9487-3766
Funding Agency and Grant Number
Corresponding Author Yi-Yuan Zheng, Laboratory Center, Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, No. 274 Zhijiang Middle Road, Shanghai 200071, China. iceroser@126.com
Key Words Type 1 diabetes mellitus; Akkermansia muciniphila; Immunomodulator; Gut microbiota; Clinical application
Core Tip This article offers a critical evaluation of the therapeutic potential of Akkermansia muciniphila in the context of type 1 diabetes mellitus. While the study has yielded promising results in terms of immunomodulatory effects, the absence of metabolic reversal highlights significant challenges in translating these findings into clinical applications. This article emphasizes the need for caution regarding the inhibition of immune pathways, interspecies variability, and potential ecological trade-offs within the gut microbiome. Future investigations should prioritize clinical trials and combination therapies to realize its therapeutic potential in type 1 diabetes mellitus.
Publish Date 2026-06-11 11:23
Citation

Qian Y, Xu J, Wang JM, Wu XL, Zheng YY. Letter to the Editor: Akkermansia muciniphila serves as an immunomodulator for type 1 diabetes mellitus: Promises and pitfalls. World J Diabetes 2026; 17(6): 117542

URL https://www.wjgnet.com/1948-9358/full/v17/i6/117542.htm
DOI https://doi.org/10.4239/wjd.117542
Full Article (PDF) WJD-17-117542-with-cover.pdf
Manuscript File 117542_Auto_Edited_132718.docx
Answering Reviewers 117542-answering-reviewers.pdf
Audio Core Tip 117542-audio.m4a
Conflict-of-Interest Disclosure Form 117542-conflict-of-interest-statement.pdf
Copyright License Agreement 117542-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 117542-non-native-speakers.pdf
Peer-review Report 117542-peer-reviews.pdf
Scientific Misconduct Check 117542-scientific-misconduct-check.png
Scientific Editor Work List 117542-scientific-editor-work-list.pdf
CrossCheck Report 117542-crosscheck-report.pdf