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Articles Published Processes
8/11/2026 6:12:03 AM | Browse: 5 | Download: 1
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Received |
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2025-12-10 00:47 |
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Peer-Review Started |
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2025-12-10 00:47 |
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First Decision by Editorial Office Director |
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2026-02-03 10:15 |
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Return for Revision |
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2026-02-03 10:15 |
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Revised |
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2026-02-14 14:22 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-09 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-09 07:01 |
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Articles in Press |
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2026-03-09 07:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-20 01:39 |
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Publish the Manuscript Online |
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2026-08-11 06:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Editorial |
| Article Title |
From polymorphism to phenotype: FADS2 rs174538, fatty acid signatures and disease activity in japanese crohn’s disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Si-Rui Wang, Ting-Lan Cao and Hui-Zhong Jiang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hui-Zhong Jiang, PhD, Professor, Researcher, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Beijing 100700, China. jianghz93@126.com |
| Key Words |
Crohn’s disease; FADS2; rs174538; Fatty acids; Desaturase index; Arachidonic acid; Observational study |
| Core Tip |
FADS variants shape PUFA fatty-acid profiles, but it is uncertain whether this matters in Crohn’s disease. Matsuzawa et al. bring this question into a CD cohort by linking rs174538 to stable erythrocyte membrane fatty-acid patterns and desaturase indices. Notably, the relationship between an erythrocyte delta-6 desaturase index and CDAI was present only in rs174538 wild-type carriers and disappeared in mutant carriers. This highlights that the same metabolic marker can carry different clinical information depending on genetic background, offering a clearer framework for interpreting lipid biomarkers and inconsistent omega-3 (n-3) PUFAs trial results in IBD. |
| Publish Date |
2026-08-11 06:12 |
| Citation |
Wang SR, Cao TL, Jiang HZ. From polymorphism to phenotype: FADS2 rs174538, fatty acid signatures and disease activity in japanese crohn’s disease. World J Gastroenterol 2026; 32(33): 117562
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i33/117562.htm |
| DOI |
https://doi.org/10.3748/wjg.117562 |
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