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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 117582
Country China
Received
2025-12-11 02:06
Peer-Review Started
2025-12-11 02:06
First Decision by Editorial Office Director
2025-12-26 09:52
Return for Revision
2025-12-26 09:52
Revised
2026-01-05 13:24
Publication Fee Transferred
2026-01-08 08:13
Second Decision by Editor
2026-01-27 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-27 07:36
Articles in Press
2026-01-27 07:36
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-24 09:35
Publish the Manuscript Online
2026-06-09 09:23
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title Prognostic significance of baseline C-reactive protein/albumin ratio for long-term outcomes in advanced gastric cancer under immunochemotherapy
Manuscript Source Unsolicited Manuscript
All Author List Shuai Mei, Mei-Ling Ye, Qiu-Lin Hao, Geng-Chen Li, Zhi-Yuan Yao and Hai-Yan Wang
ORCID
Author(s) ORCID Number
Hai-Yan Wang http://orcid.org/0009-0002-4508-9187
Funding Agency and Grant Number
Corresponding Author Hai-Yan Wang, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Quanshan District, Xuzhou 221000, Jiangsu Province, China. xzhaiyan68@163.com
Key Words Gastric cancer; C-reactive protein/albumin ratio; Programmed death-1 inhibitor; Predictive model; Efficacy; Safety
Core Tip The baseline C-reactive protein/albumin ratio (CAR) is a significant independent prognostic factor for advanced gastric cancer patients receiving combination immunotherapy and chemotherapy, with lower CAR levels associated with improved progression-free survival, overall survival, and higher objective response and disease control rates. By incorporating both inflammatory and nutritional status, the CAR index provides a more comprehensive evaluation of the immune microenvironment compared to traditional single inflammatory biomarkers. The CAR-integrated nomogram shows strong predictive accuracy, guiding personalized immunotherapy strategies. However, prospective, multi-center studies are needed to validate and refine its clinical applicability.
Publish Date 2026-06-09 09:23
Citation

Mei S, Ye ML, Hao QL, Li GC, Yao ZY, Wang HY. Prognostic significance of baseline C-reactive protein/albumin ratio for long-term outcomes in advanced gastric cancer under immunochemotherapy. World J Gastrointest Oncol 2026; 18(6): 117582

URL https://www.wjgnet.com/1948-5204/full/v18/i6/117582.htm
DOI https://doi.org/10.4251/wjgo.v18.i6.117582
Full Article (PDF) WJGO-18-117582-with-cover.pdf
Manuscript File 117582_Auto_Edited_124710-YJP.docx
Answering Reviewers 117582-answering-reviewers.pdf
Audio Core Tip 117582-audio.mp3
Biostatistics Review Certificate 117582-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 117582-conflict-of-interest-statement.pdf
Copyright License Agreement 117582-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 117582-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 117582-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 117582-non-native-speakers.pdf
Peer-review Report 117582-peer-reviews.pdf
Scientific Misconduct Check 117582-scientific-misconduct-check.png
Scientific Editor Work List 117582-scientific-editor-work-list.pdf
CrossCheck Report 117582-crosscheck-report.pdf