Publication Name	World Journal of Gastroenterology
Manuscript ID	11759
Country	Germany

Received	2014-06-03 09:20
Peer-Review Started	2014-06-03 19:52
To Make the First Decision	2014-08-15 12:13
Return for Revision	2014-08-19 16:22
Revised	2014-09-25 00:00
Second Decision	2014-11-10 16:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-11-19 09:17
Articles in Press	2014-11-19 09:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-10 19:23
Publish the Manuscript Online	2015-02-09 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	High-grade dysplasia, restricted to the basal cell layer involving the entire esophagus
Manuscript Source	Unsolicited Manuscript
All Author List	Mario Sarbia, Stefan Wolfer, Diana Karimi and Albert Eimiller
Funding Agency and Grant Number
Corresponding Author	Mario Sarbia, Professor, Pathology Munich-North, Ernst-Platzstrasse 2, 80992 Munich, Germany. sarbia@pathologie-muenchen.de
Key Words	Basal cell compartment; Esophagus; p53-mutation; World Health Organization-classification; Squamous cell dysplasia
Core Tip	An unusual case of high-grade squamous cell dysplasia involving the entire esophagus with dysplastic cells located exclusively in the basal portion of the esophageal squamous epithelium is reported. The analyses of results from step-biopsies of the entire esophagus were obtained using histologic and immunohistochemical analyses. Molecular pathologic analysis showed mutation of the p53 gene. The current World Health Organization (WHO) definition of high-grade squamous dysplasia requires full-thickness involvement of the squamous epithelium, which was not present in the current case. Therefore, we recommend that the WHO criteria should be reconsidered and revised.
Publish Date	2015-02-09 17:58
Citation	Sarbia M, Wolfer S, Karimi D, Eimiller A. High-grade dysplasia, restricted to the basal cell layer involving the entire esophagus. World J Gastroenterol 2015; 21(5): 1663-1665
URL	http://www.wjgnet.com/1007-9327/full/v21/i5/1663.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i5.1663

Full Article (PDF)	WJG-21-1663.pdf
Full Article (Word)	WJG-21-1663.doc
Manuscript File	11759-Review.docx
Answering Reviewers	11759-Answering reviewers.pdf
Copyright License Agreement	11759-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11759-Language certificate.pdf
Peer-review Report	11759-Peer review(s).pdf
Scientific Misconduct Check	11759-CrossCheck.jpg
Scientific Editor Work List	11759-Scientific editor work list.pdf