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5/6/2026 8:34:25 AM | Browse: 5 | Download: 8
Publication Name World Journal of Gastroenterology
Manuscript ID 117611
Country United States
Received
2025-12-11 01:25
Peer-Review Started
2025-12-11 01:25
First Decision by Editorial Office Director
2026-01-23 09:24
Return for Revision
2026-01-23 09:24
Revised
2026-02-02 03:48
Publication Fee Transferred
Second Decision by Editor
2026-03-03 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-03 07:08
Articles in Press
2026-03-03 07:08
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-21 01:00
Publish the Manuscript Online
2026-05-06 08:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Correspondence
Article Title Letter to the Editor: Leucine-rich α-2-glycoprotein in Taiwanese inflammatory bowel disease: Strengths and limitations of a novel serum marker
Manuscript Source Invited Manuscript
All Author List Rupa Guha and Aditi Banerjee
ORCID
Author(s) ORCID Number
Rupa Guha http://orcid.org/0000-0002-9341-3415
Aditi Banerjee http://orcid.org/0000-0003-1608-2998
Funding Agency and Grant Number
Corresponding Author Aditi Banerjee, Associate Professor, Department of Pediatrics, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, United States. aditi.banerjee@som.umaryland.edu
Key Words Leucine-rich α2 glycoprotein; Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; Endoscopic activity; Serum biomarker; Fecal calprotectin
Core Tip Leucine-rich α-2-glycoprotein (LRG) is an emerging serum biomarker that showed modest but incremental value for predicting endoscopic activity in Taiwanese patients with ulcerative colitis and Crohn’s disease, particularly when combined with C-reactive protein, hemoglobin, and albumin. This Letter highlights methodological issues and clinical implications of LRG testing, including its lower accuracy than fecal calprotectin, single-center data, and lack of standardized cutoffs, and argues that future multicenter, multi-ethnic studies should position LRG within composite biomarker panels and stepwise algorithms for noninvasive assessment of inflammatory bowel disease activity.
Publish Date 2026-05-06 08:34
Citation

Guha R, Banerjee A. Letter to the Editor: Leucine-rich α-2-glycoprotein in Taiwanese inflammatory bowel disease: Strengths and limitations of a novel serum marker. World J Gastroenterol 2026; 32(18): 117611

URL https://www.wjgnet.com/1007-9327/full/v32/i18/117611.htm
DOI https://dx.doi.org/10.3748/wjg.v32.i18.117611
Full Article (PDF) WJG-32-117611-with-cover.pdf
Manuscript File 117611_Auto_Edited-YJP.docx
Answering Reviewers 117611-answering-reviewers.pdf
Audio Core Tip 117611-audio.m4a
Conflict-of-Interest Disclosure Form 117611-conflict-of-interest-statement.pdf
Copyright License Agreement 117611-copyright-assignment.pdf
Peer-review Report 117611-peer-reviews.pdf
Scientific Misconduct Check 117611-scientific-misconduct-check.png
Scientific Editor Work List 117611-scientific-editor-work-list.pdf
CrossCheck Report 117611-crosscheck-report.pdf