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8/20/2026 6:54:18 AM | Browse: 1 | Download: 0
Publication Name World Journal of Stem Cells
Manuscript ID 117617
Country China
Received
2026-01-04 08:28
Peer-Review Started
2026-01-04 08:28
First Decision by Editorial Office Director
2026-01-16 03:46
Return for Revision
2026-01-16 03:46
Revised
2026-03-31 06:25
Publication Fee Transferred
Second Decision by Editor
2026-06-15 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-15 07:00
Articles in Press
2026-06-15 07:00
Edit the Manuscript by Language Editor
2026-06-28 19:08
Typeset the Manuscript
2026-08-13 03:03
Publish the Manuscript Online
2026-08-20 06:54
ISSN 1948-0210 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Basic Study
Article Title Dynamic regulation of neural stem cell state transitions by NOTCH1-REST transcriptional axis
Manuscript Source Unsolicited Manuscript
All Author List Zhi-Chong Xie, Xiao-Yong Zhao, Rui-Hua Xiong, Xiao-Li Zhang and Wei Yang
ORCID
Author(s) ORCID Number
Zhi-Chong Xie http://orcid.org/0000-0002-0657-4190
Xiao-Yong Zhao http://orcid.org/0009-0006-3445-3448
Rui-Hua Xiong http://orcid.org/0009-0002-1027-7137
Xiao-Li Zhang http://orcid.org/0000-0002-2441-2689
Wei Yang http://orcid.org/0009-0005-6974-9583
Funding Agency and Grant Number
Funding Agency Grant Number
Guangzhou Municipal Science and Technology Bureau University Project 2025A03J3232
Guangdong Provincial Graduate Education Innovation Project 2024JGXM_158
Futian District Health and Wellness Project of Shenzhen FTWS059
Corresponding Author Wei Yang, Department of Physical Examination, Guangzhou Xinhai Hospital, No. 167 Xingang West Road, Haizhu District, Guangzhou 510275, Guangdong Province, China. yuki20152025@163.com
Key Words Neural stem cells; Neurogenic locus notch homolog protein 1-RE1-silencing transcription factor axis; Epigenetic; Organoid model; Neural repair
Core Tip This study unveils the neurogenic locus notch homolog protein 1-RE1-silencing transcription factor axis as a pivotal molecular switch controlling neural stem cell dormancy-activation transitions. By integrating transcriptional, epigenetic, and metabolic analyses, it elucidates the dynamic regulatory interplay of neurogenic locus notch homolog protein 1 and RE1-silencing transcription factor, offering crucial insights into neural stem cell state transitions. The findings present promising targets for central nervous system injury repair and regenerative therapies for neurodegenerative diseases.
Publish Date 2026-08-20 06:54
Citation

Xie ZC, Zhao XY, Xiong RH, Zhang XL, Yang W. Dynamic regulation of neural stem cell state transitions by NOTCH1-REST transcriptional axis. World J Stem Cells 2026; 18(8): 117617

URL https://www.wjgnet.com/1948-0210/full/v18/i8/117617.htm
DOI https://doi.org/10.4252/wjsc.117617
Full Article (PDF) WJSC-18-117617-with-cover.pdf
The ARRIVE Guidelines 117617-The-ARRIVE-Guidelines.pdf
Manuscript File 117617_Auto_Edited_020435.docx
Answering Reviewers 117617-answering-reviewers.pdf
Audio Core Tip 117617-audio.mp3
Biostatistics Review Certificate 117617-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 117617-conflict-of-interest-statement.pdf
Copyright License Agreement 117617-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 117617-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate 117617-non-native-speakers.pdf
Supplementary Material 117617-supplementary-material.pdf
Peer-review Report 117617-peer-reviews.pdf
Scientific Misconduct Check 117617-scientific-misconduct-check.png
CrossCheck Report 117617-crosscheck-report.pdf