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Articles Published Processes
6/25/2026 8:21:20 AM | Browse: 0 | Download: 0
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Received |
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2026-01-20 10:00 |
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Peer-Review Started |
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2026-01-20 10:00 |
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First Decision by Editorial Office Director |
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2026-01-29 08:32 |
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Return for Revision |
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2026-01-29 08:32 |
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Revised |
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2026-02-07 09:46 |
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Publication Fee Transferred |
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2026-02-12 13:26 |
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Second Decision by Editor |
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2026-03-23 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-30 13:11 |
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Articles in Press |
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2026-03-30 13:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-12 14:03 |
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Publish the Manuscript Online |
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2026-06-25 08:21 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Ling Hu, Zhong-Xiang Lin, Xiao-Yue Zhang, Guo-Li Li, Wei-Jie Liu, Zhong-Quan Shi, Xiao-Han Li and Zhen-Zhou Yang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhen-Zhou Yang, Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjiang Road, Chongqing 400000, China. yangzz@cqmu.edu.cn |
| Key Words |
Radiation-induced lung injury; Mitoquinone; Mesenchymal stem cells; Mitochondrial oxidative stress; Synergistic therapy |
| Core Tip |
Radiation-induced lung injury (RILI) remains a major limitation in thoracic radiotherapy, driven by oxidative stress, mitochondrial dysfunction, and inflammation-fibrosis progression. Mesenchymal stem cells offer therapeutic potential but have limited survival in oxidative environments. This study demonstrates that combining the mitochondria-targeted antioxidant mitoquinone with mesenchymal stem cells significantly enhances treatment efficacy in a murine RILI model. The combination therapy improved lung function, reduced oxidative stress, restored mitochondrial homeostasis, and attenuated inflammation and fibrosis more effectively than either monotherapy. These findings highlight a dual-target strategy that optimizes stem cell-based interventions, offering a promising approach for RILI management. |
| Publish Date |
2026-06-25 08:21 |
| Citation |
Hu YL, Lin ZX, Zhang XY, Li GL, Liu WJ, Shi ZQ, Li XH, Yang ZZ. Combining mitochondrial antioxidant mitoquinone and mesenchymal stem cell therapy for amelioration of radiation-induced lung injury: Synergistic regenerative strategy. World J Stem Cells 2026; 18(6): 117622
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i6/117622.htm |
| DOI |
https://doi.org/10.4252/wjsc.117622 |
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