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Articles Published Processes
3/13/2026 8:28:16 AM | Browse: 1 | Download: 0
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Received |
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2025-12-12 00:01 |
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Peer-Review Started |
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2025-12-12 00:01 |
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First Decision by Editorial Office Director |
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2026-01-07 08:42 |
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Return for Revision |
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2026-01-07 08:42 |
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Revised |
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2026-01-15 13:55 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-09 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-09 10:02 |
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Articles in Press |
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2026-02-09 10:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-11 00:38 |
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Publish the Manuscript Online |
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2026-03-13 08:28 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Major histocompatibility complex class I chain-related A and B molecules and their potential role in virus-associated cancers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abdellatif Bouayad |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abdellatif Bouayad, Associate Professor, MD, Department of Immunology, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Mohammed V Avenue, Oujda-Angad 4867, Oriental, Morocco. abdellatifbouayad@hotmail.fr |
| Key Words |
Major histocompatibility complex class I chain-related genes A; Major histocompatibility complex class I chain-related genes B; Virus-associated cancers; Polymorphism; Natural killer group 2-member D; Natural killer-cell cytotoxicity |
| Core Tip |
Several oncogenic viruses have evolved multi-layered strategies to subvert the natural killer group 2-member D (NKG2D)-major histocompatibility complex class I chain-related genes A (MICA)/B axis and promote cancer progression. Human papillomavirus drives immune evasion through exosomal release of the truncated MICA*008 variant, which potently downregulates NKG2D and impairs natural killer (NK) cell cytotoxicity. Chronic hepatitis B virus and hepatitis C virus infections create a hypoxic/inflammatory tumor milieu that induces metalloproteases, generating soluble MICA/B that suppresses NKG2D on NK and CD8+ T cells. EBV evades NKG2D-mediated immunity through miR-bamHI-A rightward transcript 7-mediated repression of the transforming growth factor beta 1/cellular myelocytomatosis oncogene/MICA axis and latent membrane protein 2A-driven disruption of stress-induced ligand expression, reinforced by UPR-protein disulfide isomerase inhibition of proper MICA/MICB folding and trafficking. Kaposi’s sarcoma-associated herpesvirus exploits its E3 ubiquitin ligases K3 and K5 to ubiquitinate MICA and other NK-activating ligands such as activation-induced C-type lectin, triggering their endocytic removal and intracellular sequestration to disable multiple NK cell recognition pathways. Therapeutic strategies targeting this axis show considerable promise. |
| Publish Date |
2026-03-13 08:28 |
| Citation |
Bouayad A. Major histocompatibility complex class I chain-related A and B molecules and their potential role in virus-associated cancers. World J Virol 2026; 15(1): 117643 |
| URL |
https://www.wjgnet.com/2220-3249/full/v15/i1/117643.htm |
| DOI |
https://dx.doi.org/10.5501/wjv.v15.i1.117643 |
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