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Articles Published Processes
4/20/2026 8:05:36 AM | Browse: 24 | Download: 212
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Received |
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2025-12-15 01:41 |
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Peer-Review Started |
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2025-12-15 01:42 |
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First Decision by Editorial Office Director |
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2026-01-23 07:59 |
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Return for Revision |
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2026-01-23 07:59 |
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Revised |
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2026-02-10 12:22 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-09 03:03 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-16 03:53 |
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Articles in Press |
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2026-03-16 03:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-07 09:31 |
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Publish the Manuscript Online |
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2026-04-20 08:05 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Modulation of osteoarthritis-related microRNAs using locked nucleic acid-antisense oligonucleotides boosts chondrogenic lineage commitment of mesenchymal progenitors
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Marina Fontiveros-Palomino, Itziar Álvarez-Iglesias, Alberto González-González, Ana Alfonso-Fernández and Flor María Pérez-Campo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| a NEXT-VAL grant from the Instituto de Investigación Sanitaria Marqués de Valdecilla-IDIVAL |
NVAL23/06 |
| a grant from the Instituto de Investigación Marqués de Valdecilla-IDIVAL |
PREVAL 20/01 |
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| Corresponding Author |
Flor María Pérez-Campo, Assistant Professor, PhD, Senior Researcher, Department of Molecular Biology, Instituto de Investigación Sanitaria Marqués de Valdecilla, Faculty of Medicine, University of Cantabria, Avda Cardenal Herrera Oria S/N, Santander 39011, Cantabria, Spain. f.perezcampo@unican.es |
| Key Words |
Osteoarthritis; Mesenchymal stem cells; Chondrogenesis; MicroRNA; Locked nucleic acid-antisense oligonucleotides; Cartilage regeneration; Micromass culture |
| Core Tip |
Our study demonstrates that a brief ex vivo priming of mesenchymal stem cells (MSCs) with locked nucleic acid-antisense oligonucleotides targeting osteoarthritis-related microRNAs improved early chondrogenic programming. In rat MSC micromasses, the miR-30b-5p/miR-193b-3p combination produced higher Sox9 and Acan, lower Runx2, and stronger histological evidence of cartilage-like matrix than single inhibitors and controls. This transient, non-integrative strategy provides molecular fine-tuning of MSCs and has the potential to enhance the consistency and durability of MSC-based therapies for cartilage repair. |
| Publish Date |
2026-04-20 08:05 |
| Citation |
Fontiveros-Palomino M, Álvarez-Iglesias I, González-González A, Alfonso-Fernández A, Pérez-Campo FM. Modulation of osteoarthritis-related microRNAs using locked nucleic acid-antisense oligonucleotides boosts chondrogenic lineage commitment of mesenchymal progenitors. World J Stem Cells 2026; 18(4): 117652 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i4/117652.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i4.117652 |
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