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Articles Published Processes
9/22/2026 3:20:35 AM | Browse: 1 | Download: 0
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Received |
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2025-12-22 07:43 |
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Peer-Review Started |
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2025-12-22 07:43 |
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First Decision by Editorial Office Director |
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2026-01-28 09:22 |
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Return for Revision |
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2026-01-28 09:22 |
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Revised |
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2026-03-05 22:43 |
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Publication Fee Transferred |
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2026-03-09 07:09 |
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Second Decision by Editor |
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2026-09-02 02:53 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-04 09:02 |
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Articles in Press |
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2026-09-04 09:02 |
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Edit the Manuscript by Language Editor |
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2026-09-06 13:07 |
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Typeset the Manuscript |
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2026-09-14 08:26 |
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Publish the Manuscript Online |
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2026-09-22 03:20 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the experimental colitis by maintaining intestinal barrier and remodeling macrophage polarization
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lian-Lian Tian, Jun Zhu, Zhen-Zhen Fan, Yan-Ting Shi, Liu-Qing Zhao, Jin-Dan He and Jie Liang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82370588 |
| National Natural Science Foundation of China |
No. 82570614 |
| National Natural Science Foundation of China |
No. 92259302 |
| The Innovative Medical Research Boosting Project |
No. XJZT25CX41 |
| Special Project for Clinical New Technologies of Xijing Hospital |
No. 2024XJSY17 |
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| Corresponding Author |
Jie Liang, MD, PhD, Professor, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, No. 127 Changle West Road, Xincheng District, Xi’an 710032, Shaanxi Province, China. liangjie@fmmu.edu.cn |
| Key Words |
Inflammatory bowel disease; Human umbilical cord mesenchymal stem cells derived-exosomes; Intestinal barrier; Macrophage phenotypic transformation; Janus kinase/signal transducer and activator of transcription signaling |
| Core Tip |
In this study, we found that human umbilical cord mesenchymal stem cell-derived exosome (hucMSC-Ex) ameliorated dextran sulfate sodium-induced colitis by reducing colonic inflammation and maintaining intestinal mucosa permeability, while promoting the transformation of immature pro-inflammatory macrophages into mature anti-inflammatory macrophages. In vitro, hucMSC-Ex also modulated the phenotypic changes in RAW264.7 cells. Furthermore, hucMSC-Ex altered the phenotypic transformation of macrophages, thereby ameliorating experimental colitis through modulation of the Janus kinase/signal transducer and activator of transcription signaling pathway in vivo and in vitro. This study not only provides guidance for further research on molecular mechanisms of inflammatory bowel disease (IBD), but also offers a theoretical basis for targeted therapy of IBD. |
| Publish Date |
2026-09-22 03:20 |
| Citation |
Tian LL, Zhu J, Fan ZZ, Shi YT, Zhao LQ, He JD, Liang J. Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the experimental colitis by maintaining intestinal barrier and remodeling macrophage polarization. World J Gastroenterol 2026; 32(42): 117657
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i42/117657.htm |
| DOI |
https://doi.org/10.3748/wjg.117657 |
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