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Articles Published Processes
5/25/2026 7:47:55 AM | Browse: 0 | Download: 0
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Received |
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2025-12-15 01:38 |
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Peer-Review Started |
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2025-12-15 01:38 |
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First Decision by Editorial Office Director |
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2026-01-16 03:40 |
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Return for Revision |
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2026-01-16 03:40 |
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Revised |
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2026-01-27 19:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-02 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-03 07:22 |
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Articles in Press |
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2026-03-03 07:22 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-13 00:26 |
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Publish the Manuscript Online |
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2026-05-25 07:47 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to clinical applications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ashwini Raja, Naveen Jeyaraman, Ashika Mudilikulam Sukumaran, Aadithya Siddarth Sridhar, Swaminathan Ramasubramanian, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com |
| Key Words |
Knee osteoarthritis; Bone marrow; Mesenchymal stromal cells; Extracellular vesicles; Exosomes; Hydrogels |
| Core Tip |
Bone marrow mesenchymal stromal cell exosomes show promise as cell-free therapeutics for knee osteoarthritis by delivering microRNAs and long noncoding RNAs that modulate nuclear factor kappa B, Wnt/β-catenin, phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin and mitogen-activated protein kinases pathways. They suppress chondrocyte apoptosis, enhance matrix synthesis, polarise macrophages, and reduce pain behaviours. Delivery innovations like hydrogels improve retention, but rigorous Minimal Information for Studies of Extracellular Vesicles 2023-compliant characterisation and adequately powered randomised trials remain essential before clinical translation as disease-modifying therapy. |
| Publish Date |
2026-05-25 07:47 |
| Citation |
Raja A, Jeyaraman N, Sukumaran AM, Sridhar AS, Ramasubramanian S, Nallakumarasamy A, Muthu S, Jeyaraman M. Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to clinical applications. World J Stem Cells 2026; 18(5): 117689 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i5/117689.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i5.117689 |
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